Creative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs has established a broad range of platforms for developing novel antibodies or equivalents. These cutting-edge technologies enable our scientists to meet your demands from different aspects and tailor the most appropriate solution that contributes to the success of your projects.
HighlightsWith deep understanding in antibody-related realms and extensive project experience, Creative Biolabs offers a variety of references to help you learn more about our capacities and achievements, including infographic, flyer, case study, peer-reviewed publications, and all kinds of knowledge that can assist your projects. You are also welcome to contact us directly for more specific solutions.
HighlightsGet a real taste of Creative Biolabs, one of the most professional custom service providers in the world. We are committed to providing highly customized comprehensive solutions with the best quality to advance your projects.
HighlightsThe calcitonin receptor family consists of two receptors: the calcitonin receptor (CTR or CALCR) and the calcitonin gene-related peptide receptor (CGRPR). CTR binds calcitonin, which is a polypeptide hormone capable of decreasing blood calcium, while CGRPR binds calcitonin gene-related peptide (CGRP), which is a potent vasodilator responsible for the stimulation of the glomerular filtration rate. CTRs are highly expressed on osteoclasts and are important therapeutic targets for treatment of bone disorders. Besides, they are also expressed on other cell surfaces and are implicated in different diseases. CGRPRs are derived from calcitonin receptor-like receptor (CLR), whose phenotype is determined by coexpression with receptor activity-modifying protein (RAMP). CGRPRs are reported to be implicated in different cardiovascular diseases and migraine. Both CLR and CTR are seven-transmembrane-domain G protein-coupled receptors.
Here, we give an introduction of these two calcitonin receptor members regarding their distribution, structure, basic information, functions, their implication in different diseases, etc. Moreover, we present the recent research advances of these two receptors regarding their molecular mechanisms and drug development.
Additionally, here we present our cutting-edge MemDX™ membrane protein production platform, which utilizes various technologies to stabilize/solubilize your membrane protein targets of interest. Specifically, we provide reconstitution systems such as detergent micelles, proteoliposomes, nanodiscs, MP-VLPs, and polymers for our clients to choose from. We can select appropriate detergents and lipids for use with a specific membrane protein. Moreover, we can provide stably transfected cell lines that overexpress the target proteins.
In addition, aided by our MemDX™ membrane protein antibody discovery platform, we can customize the antibody discovery services against your proteins. Our scientists have accumulated years of valued experience in the completion of difficult-to-prepare membrane proteins and we pursue to provide best-quality products that maximally preserve the structural and functional integrity. We also present DNA immunization service for anti-membrane protein antibody development. Please feel free to contact us for more information.
All listed services and products are For Research Use Only. Do Not use in any diagnostic or therapeutic applications.
