Creative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs has established a broad range of platforms for developing novel antibodies or equivalents. These cutting-edge technologies enable our scientists to meet your demands from different aspects and tailor the most appropriate solution that contributes to the success of your projects.
HighlightsWith deep understanding in antibody-related realms and extensive project experience, Creative Biolabs offers a variety of references to help you learn more about our capacities and achievements, including infographic, flyer, case study, peer-reviewed publications, and all kinds of knowledge that can assist your projects. You are also welcome to contact us directly for more specific solutions.
HighlightsGet a real taste of Creative Biolabs, one of the most professional custom service providers in the world. We are committed to providing highly customized comprehensive solutions with the best quality to advance your projects.
HighlightsChloride (Cl−) channels are membrane proteins, in charge of the passive flow of Cl− into and out of cells. The calcium (Ca2+)-activated chloride channels (CaCCs), also known as calcium-dependent chloride channel (Ca-ClC), are heterogeneous groups of ligand-gated ion channels for chloride. CaCCs are increasingly attracting more attention lately, as anion-selective channels that are stimulated by increases in cytosolic Ca2+. Although anoctamin-1(ANO1)/TMEM16A and anoctamin-2(ANO2)/TMEM16B as CaCCs were first identified in 2008, subsequently they have been detected in vascular endothelial cells, epithelial cells, neurons, as well as in smooth and cardiac muscle cells. In line with their widespread expression, it is reported that CaCCs participate in varieties of physiologic processes including the excitability of neurons and muscle cells, oocyte fertilization, olfactory transduction, and repolarization and action potential duration in cardiac myocytes. Within the airways, these proteins are believed to contribute to transepithelial fluid secretion.
CLCA, a family of proteins of which has been proposed to mediate the current of CaCCs, form a multigene family with several isoforms. Here shows part of the family members in humans as bellows. A recent model displayed that CLCA proteins are synthesized as 125-KD precursor proteins containing five transmembrane domains, which later is cleaved into a 90-KD NH2-terminal fragment with membrane-spanning domains 1-3 and a COOH-terminal 38-KD fragment with two transmembrane domains.
Based on advanced MemDX™ membrane protein production platform, Creative Biolabs would like to offer the preparation of these targets in required formats by using numerious strategies, including detergent micelles, proteoliposomes, nanodiscs, MP-VLPs, polymers, stable cell line.
Besides, our versatile MemDX™ membrane protein antibody discovery platform can help screen and find antibodies against these targets, even fully humanized antibodies, via varieties of technologies such as hybridoma technology, phage display technology, and so on. Besides, we also present DNA immunization service for anti-membrane protein antibody development. Please feel free to contact us for more details.
All listed services and products are For Research Use Only. Do Not use in any diagnostic or therapeutic applications.
