Creative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsWith over a decade of experience in phage display technology, Creative Biolabs can provide a series of antibody or peptide libraries that are available for licensing or direct screening. These ready-to-use libraries are invaluable resources for isolating target-specific binders for various research, diagnostic or therapeutic applications. Highlights
Creative Biolabs has established a broad range of platforms for developing novel antibodies or equivalents. These cutting-edge technologies enable our scientists to meet your demands from different aspects and tailor the most appropriate solution that contributes to the success of your projects.
HighlightsWith deep understanding in antibody-related realms and extensive project experience, Creative Biolabs offers a variety of references to help you learn more about our capacities and achievements, including infographic, flyer, case study, peer-reviewed publications, and all kinds of knowledge that can assist your projects. You are also welcome to contact us directly for more specific solutions.
HighlightsGet a real taste of Creative Biolabs, one of the most professional custom service providers in the world. We are committed to providing highly customized comprehensive solutions with the best quality to advance your projects.
HighlightsCalcium-activated potassium channels are potassium channels gated by calcium, or that are structurally or phylogenetically related to calcium-gated channels. They were first discovered in 1958 by Gardos who saw that calcium levels inside of a cell could affect the permeability of potassium through the cell membrane. To date, a series of members of the KCNM protein family have been identified, which exist as a complex with two different kinds of subunits, the pore-forming α subunit, and a β regulatory subunit. They are associated with and modulated by a wide variety of intra- and extracellular factors, such as auxiliary subunits (β, γ), Slobs (slo binding protein), phosphorylation, membrane voltage, chemical ligands (Ca²⁺, Mg²⁺). Studies have shown that the activity of calcium-activated potassium channels is implicated in many physiological processes, such as neurosecretion, smooth muscle tone, action potential shape and spike frequency adaptation. It has been reported that KCNM proteins could help regulate physiological processes, such as circadian behavioral rhythms and neuronal excitability. Furthermore, they are also involved in many processes in the body.
Here, we have described in detail of members of the KCNM protein family, which including but not limited to calcium-activated potassium channel subunit alpha-1, calcium-activated potassium channel subunit beta-1, and calcium-activated potassium channel subunit beta-2. To learn more detailed information, please click the links below.
Based on advanced Magic™ membrane protein production platform, Creative Biolabs is confident in offering various target membrane protein products in required formats using various strategies, such as detergent micelles, proteoliposomes, nanodiscs, lipoparticles, polymers, stable cell line.
Furthermore, our Magic™ membrane protein antibody discovery platform can help to discover antibodies against these targets, even fully humanized antibodies, by various approaches such as hybridoma technology, phage display technology. Besides, we also present DNA immunization service for anti-membrane protein antibody development. Please feel free to contact us for more information.
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