Creative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsWith over a decade of experience in phage display technology, Creative Biolabs can provide a series of antibody or peptide libraries that are available for licensing or direct screening. These ready-to-use libraries are invaluable resources for isolating target-specific binders for various research, diagnostic or therapeutic applications. Highlights
Creative Biolabs has established a broad range of platforms for developing novel antibodies or equivalents. These cutting-edge technologies enable our scientists to meet your demands from different aspects and tailor the most appropriate solution that contributes to the success of your projects.
HighlightsWith deep understanding in antibody-related realms and extensive project experience, Creative Biolabs offers a variety of references to help you learn more about our capacities and achievements, including infographic, flyer, case study, peer-reviewed publications, and all kinds of knowledge that can assist your projects. You are also welcome to contact us directly for more specific solutions.
HighlightsGet a real taste of Creative Biolabs, one of the most professional custom service providers in the world. We are committed to providing highly customized comprehensive solutions with the best quality to advance your projects.
HighlightsCalcium homeostasis modulator (CALHM) family, also known as FAM26 proteins, is a group of voltage-gated ion channel proteins (CALHM1-6). These proteins are widely expressed in the brain and taste buds throughout vertebrates and in sensory neurons and body wall muscles in C. elegans. They have an essential roles in the regulation of calcium homeostasis in various cells, participating in a variety of biological processes, such as neuronal excitability, neurotransmission of tastes, and muscle cell function.
CALHM1 have been shown to mediate of neuronal intracellular calcium homeostasis and signaling, and calcium-dependent neuronal excitability and memory in mouse models. In human, CALHM1 regulates the Ca2+ dependent MEK, ERK, RSK and MSK signalling cascade in neurons. It may be associated with the pathogenesis of Alzheimer's disease (AD). CALHM2/CALHM3 is a paralogue of CALHM1 that participates in the controlling neuronal excitability. CALHM4/CALHM5/CALHM6 is probably a pore-forming subunit of a voltage-gated ion channel. The following table further illustrates some members of the family.
Creative Biolabs is proud to use our cutting-edge Magic™ membrane protein production platform to offer the preparation of these targets in required formats. We also provide various strategies including detergent micelles, proteoliposomes, nanodiscs, lipoparticles, polymers, stable cell line.
Especially, our Magic™ membrane protein antibody discovery platform is a comprehensive platform to discover antibodies against these targets, even fully humanized antibodies. Various approaches are adopted in this platform to make better-personalized customization and service, including hybridoma technology, phage display technology, etc. Besides, we also present DNA immunization service for anti-membrane protein antibody development. Please feel free to contact us for more information.
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