Creative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs has established a broad range of platforms for developing novel antibodies or equivalents. These cutting-edge technologies enable our scientists to meet your demands from different aspects and tailor the most appropriate solution that contributes to the success of your projects.
HighlightsWith deep understanding in antibody-related realms and extensive project experience, Creative Biolabs offers a variety of references to help you learn more about our capacities and achievements, including infographic, flyer, case study, peer-reviewed publications, and all kinds of knowledge that can assist your projects. You are also welcome to contact us directly for more specific solutions.
HighlightsGet a real taste of Creative Biolabs, one of the most professional custom service providers in the world. We are committed to providing highly customized comprehensive solutions with the best quality to advance your projects.
Highlights| Protein Name | Calcitonin receptor |
| Gene Name | CALCR |
| Uniprot | P30988 (Human); Q60755 (Mouse) |
| Synonym | CRT; CTR; CT-R; CTR1 |
| Background | The calcitonin is a polypeptide hormone that is able to decrease blood calcium levels by direct inhibition of mediated bone resorption and by enhancing calcium excretion by the kidney. The activities of calcitonin are mediated by high-affinity calcitonin receptors (CTRs or CALCRs). The CALCR is a class B G-protein coupled receptor. This family of receptors is characterized by seven transmembrane segments connected by three extracellular loops. The human CALCR gene is located on chromosome 7. This receptor is able to couple at least two signal transduction pathways: the cAMP signal transduction and the phospholipase C enzyme pathway. |
Creative Biolabs offers comprehensive range of membrane protein products empowers your unique research needs.
| CAT# | Product Name | Expression System | Protein Length | Solubilizing Agents |
| S01YF-1023-KX297 | NativeExtract™ Human CALCR Membrane Protein (Full length, Super Nanodisc) | HEK293 cell | Full length | Native Nanodisc |
| MPX3593K | MemDX™ Membrane Protein Human CALCR Expressed in vitro E.coli expression system, Full Length of Mature Protein | E.coli cell-free | Full length | Detergent |
| MP0155X | MemDX™ Membrane Protein Human CALCR (Calcitonin receptor) for Antibody Discovery | Wheat germ cell-free | Full length | N/A |
| Please for more products or customization | ||||
M**a: Ideal for complex structural studies requiring precise post-translational modifications.
22/Aug/2023
A***a: Their tailored expression systems delivered endotoxin-free CALCR within 4 weeks.
07/Mar/2024
CALCR Gene Therapy Development
We provide tailored solutions to meet your specific requirements. Please for more services.
CALCR Gene Editing
Creative Biolabs offers CALCR gene editing services. Gene editing technology enables precise modulation of the CALCR locus, offering therapeutic potential for disorders linked to CALCR dysregulation, such as metabolic and neuroendocrine pathologies. By introducing single-guide RNAs tailored to CALCR-specific sequences, researchers can correct gain- or loss-of-function mutations in preclinical models. Creative Biolabs' proprietary RNA design platforms enhance specificity, minimizing off-target effects while maximizing on-target editing efficiency. For instance, recent preclinical studies demonstrate successful normalization of calcium homeostasis in osteoporotic models via CALCR knock-in strategies, underscoring this approach's translational viability.
Recombinant AAV Vectors for CALCR Overexpression
Creative Biolabs offers recombinant AAV vectors development services for CALCR overexpression. Adeno-associated virus (AAV) vectors engineered for tissue-specific tropism enable controlled CALCR overexpression in target cells. This modality shows promise for treating conditions like hypocalcemia, where CALCR signaling deficits impair calcium sensing. Creative Biolabs' AAV serotype screening services facilitate rapid identification of optimal vectors for hepatic or neuronal delivery, as evidenced by recent in vivo work restoring calcium-responsive hormone secretion in parathyroid-deficient models. Such advancements highlight the clinical relevance of CALCR-targeted gene augmentation.
RNA Interference for CALCR Silencing
Creative Biolabs offers RNA interference services. Antisense oligonucleotides (ASOs) and small interfering RNAs (siRNAs) provide a reversible mechanism to suppress pathological CALCR overexpression, particularly in hypercalcemic states or CALCR-driven tumors. Creative Biolabs' lipid nanoparticle (LNP) encapsulation technology enhances siRNA stability and delivery to bone marrow or thyroid tissues, as validated in preclinical models achieving >70% CALCR mRNA knockdown without systemic toxicity. This approach supports the development of first-in-class therapies for CALCR-associated malignancies.
Creative Biolabs offers comprehensive and innovative services to drive the development of CALCR cell therapy. Please for more services.
CAR-T Cell Engineering for CALCR-Expressing Tumors
Creative Biolabs offers CAR-T cell engineering services. Chimeric antigen receptor (CAR)-T cells targeting CALCR surface epitopes exhibit potent cytotoxicity against medullary thyroid carcinomas and other CALCR-positive malignancies. Creative Biolabs' CAR construct optimization services integrate scFv domains with enhanced CALCR binding affinity, coupled with safety switches to mitigate cytokine release syndrome. Recent phase I trials report 60% objective response rates in refractory CALCR+ tumors, positioning this strategy as a cornerstone of next-generation oncology pipelines.
Induced Pluripotent Stem Cell (iPSC) Differentiation
Creative Biolabs offers iPSC differentiation services. CALCR-expressing iPSC-derived cells offer regenerative potential for bone and neuroendocrine tissues. By modulating WNT and BMP signaling pathways, Creative Biolabs' differentiation protocols generate functional osteoblasts and parafollicular cells with restored CALCR activity in vitro. This platform holds transformative potential for osteoporosis and inherited CALCR deficiencies, as demonstrated by in vivo engraftment studies achieving 30% bone density recovery in murine models.
CALCR-Specific Viral Vector Transduction
Creative Biolabs offers CALCR-specific viral vector transduction services. Lentiviral vectors encoding CALCR under tissue-specific promoters enable durable receptor expression in adoptive cell therapies. Creative Biolabs' vector engineering expertise ensures high transduction efficiency (>90%) in T cells or hematopoietic stem cells, critical for sustaining CALCR signaling in vivo. Preclinical data show improved survival in models of chronic hypocalcemia, with no vector-related genotoxicity observed over 12-month follow-up periods.
The intricate interplay between CALCR biology and therapeutic modality selection necessitates expert guidance. Creative Biolabs' multidisciplinary team offers end-to-end support—from target validation to IND-enabling studies—leveraging cutting-edge platforms in gene editing, viral vector design, and cell therapy optimization. to explore how our tailored solutions can accelerate your CALCR program's transition from bench to bedside.
All listed services and products are For Research Use Only. Do Not use in any diagnostic or therapeutic applications.
