CALHM6 Membrane Protein Introduction

Introduction of CALHM6

CALHM6, also called FAM26F, is encoded by the CALHM6 gene. CALHM6 is a relatively recently identified gene reported to play important role in diverse immune responses. Numerous studies have reported CALHM6 to be differentially expressed in a variety of viral, bacterial and parasitic infections, in certain pathophysiological conditions, such as heart and liver transplantation, and in several cancers.

Basic Information of CALHM6
Protein Name Calcium homeostasis modulator protein 6
Gene Name CALHM6
Aliases Protein FAM26F, C6orf187, FAM26F
Organism Homo sapiens (Human)
UniProt ID Q5R3K3
Transmembrane Times 4
Length (aa) 315

Function of CALHM6 Membrane Protein

CALHM6 is up-regulated by various agonists such as polyI: C, LPS, INFγ, and TNFα. The synergistic expression of CALHM6 on NK cells and bone marrow dendritic cells is required for activation of NK cells targeting tumors through its cytoplasmic tail, so CALHM6 pairs NK-sensitive tumors have a certain therapeutic potential. Studies have found that CALHM6 expression level is a marker of IFN-γ-lead immune response and is considered an early diagnostic marker. CALHM6 is also considered to be a mysterious protein with complex effects in the immune system.

Anti-tumor activation pathways of CALHM6. Fig.1 Anti-tumor activation pathways of CALHM6. (Malik, 2016)

Application of CALHM6 Membrane Protein in Literature

  1. Javed A., et al. Pre-infection transcript levels of FAM26F in peripheral blood mononuclear cells inform about overall plasma viral load in acute and post-acute phase after simian immunodeficiency virus infection. J Gen Virol. 2016, 97(12): 3400-3412. PubMed ID: 27902344

    The article showed that CALHM6 is expressed in CD4+ T cells and B cells and is one of the earliest prognostic markers, contributing to the progression of disease prior to SIV infection by major histocompatibility complex (MHC)-typing.

  2. Malik U., et al. Structural and functional annotation of human FAM26F: A multifaceted protein having a critical role in the immune system. Gene. 2017, 597: 66-75. PubMed ID: 27784631

    This article reveals that the computer structure and functional characterization of CALHM6 can help us better understand the role of CALHM6 in the immune system and may serve as a new therapeutic target.

  3. Ma Z., et al. Calcium homeostasis modulator (CALHM) ion channels. Journal of Physiology. 2016, 468(3): 395-403.

    The article demonstrated that CALHM plays an important role in physiology as a voltage and Ca2+ o-gated ion channel that penetrates large cations and anions.

  4. Gisbert J.P., et al. Tu1943a A Genome-Wide Association Study Identifies DSE-FAM26F As a Risk Locus for Ulcerative Colitis. Gastroenterology. 2014, 146(5): S878.

    This article indicated that DSE-CALHM6 is recognized as a risk genetic locus for ulcerative colitis.

CALHM6 Preparation Options

To obtain the soluble and functional target protein, the versatile Magic™ membrane protein production platform in Creative Biolabs enables many flexible options, from which you can always find a better match for your particular project. Aided by our versatile Magic™ anti-membrane protein antibody discovery platform, we also provide customized anti-CALHM6 antibody development services.

As a forward-looking research institute as well as a leading customer service provider in the field of membrane protein, Creative Biolabs has won good reputation among our worldwide customers for successfully accomplishing numerous challenging projects including generation of many functional membrane proteins. Please feel free to contact us for more information.


  1. Malik U and Javed A (2016). FAM26F: An Enigmatic Protein Having a Complex Role in the Immune System. Int Rev Immunol. 19, 1-11.

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