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AAStable™ Stable PCL Platform for AAV Production

All products and services are For Research Use Only and CANNOT be used in the treatment or diagnosis of disease.

The application of adeno-associated virus (AAV) vectors in large animal research and clinical trials usually require high-titer and efficient vectors. However, many currently used vector production methods based on transient transfection of cell lines or helper virus infection have their mimics.

Creative Biolabs provides innovative products and services designed to accelerate your treatment projects through the development of AAV vectors. With solutions covering the entire AAV production process, we have developed a 293 cell-based producer cell line method for high-titer and highly-potency AAV vectors.

From packaging to producer cell lines

Creative Biolabs' AAStable™ technology takes the production of viral vectors to a new level.

Through a unique producer cell line method, AAStable™ can achieve high-performance AAV vector production, thereby providing consistent quality in various types and forms of suspension bioreactors, up to large-scale production. No helper virus, expensive transfection reagent, or cGMP grade plasmid is required. Just propagate your producer cell and start production.

Schematic for AAV vector production in packaging cell line. Fig.1 Schematic for AAV vector production in packaging cell line.

Advantages of our AAStable™ Platform

Our AAStable™ Platform has the following main advantages:

(1) One-step cloning of AAV vector cassettes into serotype-specific packaging plasmids;

(2) Single plasmid transfection and selection of stable AAV vector production cell lines;

(3) Use Carriers suitable for different serotypes such as AAV2, 8, and 9;

(4) Effective packaging of single-stranded and double-stranded (self-complementary) AAV vectors;

(5) Effective packaging of large AAV cassettes (~5.0 kb).

(6) All cell lines are stable and the growth rate is the same as that of the parental 293 cells.

(7) The vector shows high efficiency of transduction in vitro and in vivo.

In short, our simple and universal AAV production cell line method can be used for large-scale AAV vector production for preclinical and clinical studies.

Our goal is to provide superior product depth and expertise to help companies develop breakthrough therapies. If you are interested in our services, please send an email to contact us, and our team will get back to you as soon as possible.

All products and services are For Research Use Only and CANNOT be used in the treatment or diagnosis of disease.

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All products and services are For Research Use Only and CANNOT be used in the treatment or diagnosis of disease.

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