Anti-CD44 DNA-encoded mAb (DMAb), pVAX1 (DMAb-1086-YY)

Datasheet

All products and services are For Research Use Only and CANNOT be used in the treatment or diagnosis of disease.

This product is the plasmid containing an encoded anti-CD44 DMAb sequence. The plasmid can drive transcription and in vivo translation of the desired antibody.

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Specifications

Target
CD44

Vector Name
pVAX1

Vector Description
pVAX1 was originally designed for the development of DNA vaccines. Its eukaryotic DNA sequences limited to the expression of desired sequence so that minimize the possibility of chromosomal integration. This vector has been widely used for the construction of DMAb plasmid.

Vector Promoter
CMV

Vector Tag or Fusion
Untagged

Delivery Method
Transfection

Cloning Method
Restriction Enzyme ⁄ MCS

Constitutive or Inducible System
Constitutive

Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term.

Background
DNA-encoded mAb (DMAb) technology is a novel approach for a direct in vivo production of desired biologically active immunoglobulins according to the plasmid DNA delivery into tissue where the delivered plasmid containing an encoded antibody sequence. Compared with the traditional mAb, DMAb can be functionally equivalent with additional advantages such as expression profiles, glycosylation, as well as no reliance on in vivo tissue culture and costly or time-consuming production systems. The DMAb technology may provide a novel, simple, less frequent, cost-effective approach for therapeutics.

Target

Entrez Gene ID
960

Sub CAT.	DMAb Clone	DMAb Host	Target Species	DMAb Isotype	DMAb Immunogen
DMAb-1086-YY	5C10	Mouse		IgG2b, κ
DMAb-1076-YY	3H1355	Mouse		IgG2b	Recognizes an epitope encoded by exons v7-v8 on the variant portion of human CD44
DMAb-0247-CN	CVS18	Mouse		IgG1
DMAb-0228-CQ	156-3C11	Mouse		IgG2a, κ	Stimulated human leukocytes
DMAb-0230-CQ	CD44v4/1219	Mouse	Human	IgG2a, κ	Recombinant fragment corresponding to the v4 domain of human CD44
DMAb-0231-CQ	CD44v4/1700R	Rabbit	Human	IgG, κ	Recombinant fragment corresponding to the v4 domain of human CD44
DMAb-0232-CQ	DF1485	Mouse		IgG1, κ	Purified CD44 antigen (PGp-1) from lymphocyte membrane
DMAb-0233-CQ	F10-44-2	Mouse	Human	IgG2a	Purified human T cells
DMAb-0234-CQ	HCAM/1097	Mouse		IgG1, κ	Recombinant human HCAM protein
DMAb-0235-CQ	HCAM/918	Mouse		IgG2a, κ	Recombinant human HCAM protein
DMAb-0236-CQ	Hermes-1	Rat		IgG2a	80-95 kDa lymphocyte surface glycoprotein H-CAM (CD44)
DMAb-0237-CQ	IM7	Rat		IgG2b	Dexamethasone-induced cells of the SJL mouse spontaneous myeloid leukemia M1
DMAb-0238-CQ	MEM-263	Mouse		IgG1	COS-7 cells, African Green Monkey (NM_000610.3)
DMAb-0239-CQ	MEM-85	Mouse	Human	IgG2b
DMAb-0240-CQ	P2A1	Mouse	Human	IgG2a	Ocular melanoma cell line (V+B2)
DMAb-0241-CQ	SPM544	Mouse		IgG2a, κ	Stimulated human leukocytes
DMAb-0242-CQ	VFF-11	Mouse	Human	IgG1	Glutathione S Transferase (GST) fusion protein corresponding to the variable domains (v3 to v10) of human CD44
DMAb-0243-CQ	VFF-17	Mouse	Human	IgG2b	Made to Human CD44v7/8
DMAb-0244-CQ	VFF-327	Mouse	Human	IgG1	Made to Human CD44v3
DMAb-0245-CQ	VFF-8	Mouse	Human	IgG1	Made to Human CD44v5
DMAb-0246-CQ	VFF-9	Mouse	Human	IgG1	Made to Human CD44v7
DMAb-0249-CQ	DB105	Mouse		IgG1
DMAb-0253-CQ	BU52	Mouse	Human	IgG1
DMAb-0254-CQ	BU75	Mouse	Human	IgG2a
DMAb-0255-CQ	hCD44	Mouse	Human	IgG1
DMAb-0256-CQ	Hermes-3	Mouse	Human	IgG2a, κ
DMAb-0257-CQ	HI44a	Mouse	Human	IgG1
DMAb-0258-CQ	SPM521	Mouse	Human	IgG2a, κ
DMAb-0260-CQ	KM201	Rat	Mouse	IgG
DMAb-0262-CQ	NKI-P2	Mouse	Human	IgG1
DMAb-0264-CQ	BSB-12	Mouse	Human	IgG2a
DMAb-0267-CQ	HCM15-1	Mouse		IgG1, κ	Purified human protein
DMAb-0175-WJ	AV6	Mouse	Chicken	IgG1
DMAb-0176-WJ	B-F24	Mouse	Human	IgG1	U937 cell line
DMAb-0253-CQ	BU52	Mouse	Human	IgG1
DMAb-0254-CQ	BU75	Mouse	Human	IgG2a
DMAb-0230-CQ	CD44v4/1219	Mouse	Human	IgG2a, κ	Recombinant fragment corresponding to the v4 domain of human CD44 (exact sequence is proprietary)
DMAb-0231-CQ	CD44v4/1700R	Rabbit	Human	IgG, κ	Recombinant fragment corresponding to the v4 domain of human CD44 (exact sequence is proprietary)
DMAb-0182-WJ	CD44v9/1459	Mouse	Human	IgG1, κ	Recombinant fragment corresponding to the v9 domain of human CD44 (exact sequence is proprietary)
DMAb-0247-CN	CVS18	Mouse	Equine	IgG1
DMAb-0233-CQ	F10-44-2	Mouse	Human	IgG2a	CD44 antibody was raised in mouse using human CD44 as the immunogen
DMAb-0255-CQ	hCD44	Mouse	Human	IgG1
DMAb-0236-CQ	Hermes-1	Rat		IgG2a	80 - 95 kDa lymphocyte surface glycoprotein H-CAM (CD44)
DMAb-0257-CQ	HI44a	Mouse	Human	IgG2a
DMAb-0237-CQ	IM7	Rat		IgG2b, κ
DMAb-0194-WJ	IM7.8.1	Rat	Mouse	IgG2b	CD44 (Ly 24, Pgp-1) (Mouse CD44)
DMAb-0260-CQ	KM201	Rat	Mouse	IgG1
DMAb-0198-WJ	KM81	Rat	Mouse	IgG2a
DMAb-0199-WJ	9A4	Rat	Mouse	IgG1
DMAb-0205-WJ	B-R8	Mouse	Human	IgG1, κ	U266 cell line
DMAb-0232-CQ	DF1485	Mouse		IgG1, κ
DMAb-0234-CQ	HCAM/1097	Mouse	Human	IgG1, κ	Recombinant human HCAM protein
DMAb-0235-CQ	HCAM/918	Mouse	Human	IgG2a, κ	Recombinant human HCAM protein
DMAb-0256-CQ	Hermes-3	Mouse	Human	IgG2a, κ	Recombinant protein corresponding to human CD44 (P16070)
DMAb-0227-WJ	J-173	Mouse	Human	IgG1	LAZ 221 ALL
DMAb-0174-YJ	3H2606	Mouse	Mouse	IgG1	Spleen cells from B6PL-Ly-2a/Ly-3a B6-Ly-1a mice.

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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

Anti-CD44 DNA-encoded mAb (DMAb), pVAX1 (DMAb-1086-YY)

Specifications

Target

Customer Reviews and Q&As

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