Anti-EGFR DNA-encoded mAb (DMAb), pVAX1 (DMAb-0771-CQ)

Datasheet

All products and services are For Research Use Only and CANNOT be used in the treatment or diagnosis of disease.

This product is the plasmid containing an encoded anti-EGFR DMAb sequence. The plasmid can drive transcription and in vivo translation of the desired antibody.

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Specifications

Target
EGFR

Vector Name
pVAX1

Vector Description
pVAX1 was originally designed for the development of DNA vaccines. Its eukaryotic DNA sequences limited to the expression of desired sequence so that minimize the possibility of chromosomal integration. This vector has been widely used for the construction of DMAb plasmid.

Vector Promoter
CMV

Vector Tag or Fusion
Untagged

Delivery Method
Transfection

Cloning Method
Restriction Enzyme ⁄ MCS

Constitutive or Inducible System
Constitutive

Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term.

Background
DNA-encoded mAb (DMAb) technology is a novel approach for a direct in vivo production of desired biologically active immunoglobulins according to the plasmid DNA delivery into tissue where the delivered plasmid containing an encoded antibody sequence. Compared with the traditional mAb, DMAb can be functionally equivalent with additional advantages such as expression profiles, glycosylation, as well as no reliance on in vivo tissue culture and costly or time-consuming production systems. The DMAb technology may provide a novel, simple, less frequent, cost-effective approach for therapeutics.

Target

Entrez Gene ID
1956

UniProt ID
P00533

Sub CAT.	DMAb Clone	DMAb Host	Target Species	DMAb Isotype	DMAb Immunogen
DMAb-0771-CQ	5BA23	Mouse	Human	IgG1, κ	Synthetic Peptide (GSHQISLDNPDYQQDFFPK (C-terminus aa 1161-1179))
DMAb-3301-FY	111.6	Mouse		IgG1
DMAb-3302-FY	13G8	Mouse		IgG1	Peptide conjugated to KLH
DMAb-3303-FY	30H45L48	Rabbit	Human	IgG
DMAb-3304-FY	31G7	Mouse	Human	IgG1, κ	Human EGF Receptor purified from A431 cells was used as the immunogen for the EGFR antibody
DMAb-3305-FY	3H2093	Rat	Human	IgG2b	Breast carcinoma cells
DMAb-3306-FY	3H2094	Mouse	Human	IgG1	Synthetic peptide sequence DVVDADEYLIPQ residues 985-996 from the sequence of the human EGF receptor
DMAb-3307-FY	423103	Rat	Human	IgG2a	Mouse myeloma cell line NS0-derived recombinant human EGF R/ErbB1, Leu25-Ser645
DMAb-3308-FY	5E10D3	Mouse	Human	IgG2b	Purified recombinant fragment of human EGFR expressed in E.coli
DMAb-3309-FY	5E10-G10-E11	Mouse		IgG1
DMAb-3310-FY	5G9B5	Mouse	Human	IgG1
DMAb-3311-FY	688CT33.1.3	Mouse	Human	IgG1	This EGFR antibody is generated from mice immunized with a KLH conjugated synthetic peptide between 1163-1191 amino acids from the C-terminal region of human EGFR
DMAb-3312-FY	7A6F12	Mouse	Human	IgG1	Recombinant fragment of human EGFR expressed in E.coli
DMAb-3313-FY	AT2H8	Mouse	Human	IgG2b, κ	Recombinant human EGFR purified from E coli
DMAb-3314-FY	D38B1	Rabbit
DMAb-3315-FY	DH8.3	Mouse	Human	IgG1	Synthetic peptide corresponding to the junctional region of the truncated receptor LEEKKGNYVVTDHC, conjugated to keyhole limpet haemcyanin
DMAb-3316-FY	EGFR.1	Mouse	Human	IgG2b, κ
DMAb-3317-FY	EGFR1	Mouse	Human	IgG2b	Human epidermoid carcinoma line A431
DMAb-3318-FY	EP38Y	Rabbit		IgG
DMAb-3319-FY	ERB7-1	Mouse	Human	IgG1, κ	Purified EGF receptor was used as the immunogen for the EGFR antibody
DMAb-3320-FY	GFR/1667	Mouse	Human	IgG1	Recombinant human full-length EGFR protein
DMAb-3321-FY	GFR1195	Mouse	Human	IgG1, κ	Recombinant human EGFR protein
DMAb-3322-FY	GFR450	Mouse	Human	IgG2a, κ	Recombinant extracellular domain of human EGFR protein
DMAb-3323-FY	GT461	Mouse	Human	IgG2a	Recombinant protein encompassing a sequence within the C-terminus region of human EGFR. The exact sequence is proprietary
DMAb-3324-FY	H9B4	Mouse	Human	IgG1	Purified EGFR from A431 cells
DMAb-3325-FY	ICR61	Rat		IgG2b
DMAb-3326-FY	M9020201	Mouse		IgG1	EGFR antibody was raised in mouse using human A431 membrane proteins as the immunogen
DMAb-3327-FY	Matuzumab	Rabbit	Human	IgG	Domain III of the extracellular domain of human EGRF
DMAb-3328-FY	me1B3	Mouse	Human	IgG1, κ
DMAb-3329-FY	MM0256-5S21	Mouse	Human	IgG2
DMAb-3330-FY	R19/48MIX	Mouse	Human	IgG1	Purified extracellular and cytoplasmic domains of human recombinant EGFR protein
DMAb-3331-FY	REA688	Human	Human	IgG1
DMAb-3332-FY	SB41a	Mouse	Human	IgG2a	Recombinant protein corresponding to human EGFR

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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

Anti-EGFR DNA-encoded mAb (DMAb), pVAX1 (DMAb-0771-CQ)

Specifications

Target

Customer Reviews and Q&As

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