Anti-MLANA DNA-encoded mAb (DMAb), pVAX1 (DMAb-2265-FY)

Datasheet

All products and services are For Research Use Only and CANNOT be used in the treatment or diagnosis of disease.

This product is the plasmid containing an encoded anti-MLANA DMAb sequence. The plasmid can drive transcription and in vivo translation of the desired antibody.

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Specifications

Target
MLANA

Vector Name
pVAX1

Vector Description
pVAX1 was originally designed for the development of DNA vaccines. Its eukaryotic DNA sequences limited to the expression of desired sequence so that minimize the possibility of chromosomal integration. This vector has been widely used for the construction of DMAb plasmid.

Vector Promoter
CMV

Vector Tag or Fusion
Untagged

Delivery Method
Transfection

Cloning Method
Restriction Enzyme ⁄ MCS

Constitutive or Inducible System
Constitutive

Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term.

Background
DNA-encoded mAb (DMAb) technology is a novel approach for a direct in vivo production of desired biologically active immunoglobulins according to the plasmid DNA delivery into tissue where the delivered plasmid containing an encoded antibody sequence. Compared with the traditional mAb, DMAb can be functionally equivalent with additional advantages such as expression profiles, glycosylation, as well as no reliance on in vivo tissue culture and costly or time-consuming production systems. The DMAb technology may provide a novel, simple, less frequent, cost-effective approach for therapeutics.

Target

Entrez Gene ID
2315

UniProt ID
Q16655

Sub CAT.	DMAb Clone	DMAb Host	Target Species	DMAb Isotype	DMAb Immunogen
DMAb-2265-FY	CBFYM-0113	Mouse	Human		Recombinant fragment of human MLANA (AA: 48-118) expressed in E. Coli
DMAb-2266-FY	CBFYM-0235	Mouse	Human	IgG1, IgG2b
DMAb-2267-FY	CBFYM-0266	Mouse	Human	IgG1, IgG2a, IgG2b
DMAb-2268-FY	CBFYM-0343	Mouse	Human	IgG1, IgG2a, IgG2b	Recombinant tyrosinase protein (T311) and extract of pigmented melanoma metastases from lymph nodes (HMB45)
DMAb-2269-FY	CBFYM-0363	Rabbit	Human	IgG	Recombinant full length human MART-1
DMAb-2270-FY	CBFYM-0364	Mouse	Human	IgG1, k	This antibody recognizes a protein doublet of 20-22kDa, identified as MART-1
DMAb-2271-FY	CBFYM-0427	Mouse	Human	IgG2b
DMAb-2272-FY	CBFYM-0431	Mouse	Human	IgG2b
DMAb-2273-FY	CBFYM-0432	Mouse	Human	IgG1
DMAb-2274-FY	CBFYM-0653	Mouse	Human	IgG1
DMAb-2275-FY	CBFYM-0654	Mouse	Human	IgG2b, k
DMAb-2276-FY	CBFYM-2270	Mouse	Human	IgG1	Recombinant protein corresponding to human MART-1. Cellular Localization: Cytoplasmic
DMAb-2277-FY	CBFYM-2271	Mouse	Human		Recombinant hMART-1 protein (A103; M2-7C10; M2-9E3). Cellular Localization: Cytoplasmic
DMAb-2278-FY	CBFYM-2272	Mouse	Human	IgG2b, k	Recombinant hMART-1 protein
DMAb-2279-FY	CBFYM-2273	Mouse	Human	IgG1	Full length human recombinant protein of human MLANA (NP_005502) produced in HEK293T cell
DMAb-2280-FY	CBFYM-2274	Mouse	Human	IgG1	Human recombinant protein fragment corresponding to amino acids 48-118 of human MLANA (NP_005502) produced in E. coli
DMAb-2281-FY	CBFYM-2275	Mouse	Human	IgG2b	Full length human recombinant protein of human MLANA(NP_005502) produced in HEK293T cell
DMAb-2282-FY	CBFYM-2276	Mouse	Human	IgG1	KLH conjugated synthetic peptide between 60-92 AA from the C-terminal region of human MART-1/Melan-A
DMAb-2283-FY	CBFYM-2277	Mouse	Human	IgG2b, k	Recombinant hMART-1 protein. MW: 18kD. Cellular Localization: Cytoplasmic
DMAb-2284-FY	CBFYM-2278	Mouse	Human	IgG1	Recombinant MART-1 protein. Cellular Localization: Cytoplasmic
DMAb-2285-FY	CBFYM-2279	Rabbit	Human	IgG	Synthetic peptide corresponding to a C-terminal sequence of human MART-1 (melanoma antigen recognized by T cells 1)
DMAb-2286-FY	CBFYM-2280	Mouse	Human	IgG2a	Recombinant human Melan-A/MART-1, Asn52-Pro118
DMAb-2287-FY	CBFYM-2281	Rabbit	Human	IgG	Recombinant human protein was used for this MART-1 antibody

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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

Anti-MLANA DNA-encoded mAb (DMAb), pVAX1 (DMAb-2265-FY)

Specifications

Target

Customer Reviews and Q&As

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