Anti-MUC1 DNA-encoded mAb (DMAb), pVAX1 (DMAb-2457-FY)

Datasheet

All products and services are For Research Use Only and CANNOT be used in the treatment or diagnosis of disease.

This product is the plasmid containing an encoded anti-MUC1 DMAb sequence. The plasmid can drive transcription and in vivo translation of the desired antibody.

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Specifications

Target
MUC1

Vector Name
pVAX1

Vector Description
pVAX1 was originally designed for the development of DNA vaccines. Its eukaryotic DNA sequences limited to the expression of desired sequence so that minimize the possibility of chromosomal integration. This vector has been widely used for the construction of DMAb plasmid.

Vector Promoter
CMV

Vector Tag or Fusion
Untagged

Delivery Method
Transfection

Cloning Method
Restriction Enzyme ⁄ MCS

Constitutive or Inducible System
Constitutive

Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term.

Background
DNA-encoded mAb (DMAb) technology is a novel approach for a direct in vivo production of desired biologically active immunoglobulins according to the plasmid DNA delivery into tissue where the delivered plasmid containing an encoded antibody sequence. Compared with the traditional mAb, DMAb can be functionally equivalent with additional advantages such as expression profiles, glycosylation, as well as no reliance on in vivo tissue culture and costly or time-consuming production systems. The DMAb technology may provide a novel, simple, less frequent, cost-effective approach for therapeutics.

Target

Entrez Gene ID
4582

UniProt ID
P15941

Sub CAT.	DMAb Clone	DMAb Host	Target Species	DMAb Isotype	DMAb Immunogen
DMAb-2457-FY	M8C9	Mouse	Human	IgG
DMAb-2458-FY	M9E7	Mouse	Human	IgG	High molecular weight glycoprotein from human milk-fat globule molecule
DMAb-0609-FY	126E7	Mouse	Human	IgM
DMAb-0610-FY	139H2	Mouse	Human	IgG1
DMAb-0611-FY	C595NCRC48	Mouse	Human	IgG3
DMAb-0612-FY	MUC1/520	Mouse	Human	IgG2a, κ	Human milk fat globule membranes were used as the immunogen for this EMA antibody
DMAb-1079-WJ	C595	Mouse	Human	IgG3

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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

Anti-MUC1 DNA-encoded mAb (DMAb), pVAX1 (DMAb-2457-FY)

Specifications

Target

Customer Reviews and Q&As

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