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Anti-NY-ESO-1 (SLIMWITQC) TCR-Like CAR [Fab (3M4F4)-28ζ], HLA-A*0201-Restricted (TLA-CA-087PZ)

The chimeric antigen receptors (CARs) have emerged as a useful tool to redirect T cells. However, despite very potent, CAR is limited to recognize membrane proteins which only comprise around 1% of the total proteins. There are plenty of attractive tumor antigens arising from intracellular proteins. TCR-like antibodies, which allow for specific targeting of intracellular proteins via MHC/peptide complexes, appear as an unexploited opportunity for antibody therapies. Therefore, introduction of an antigen-binding fragment from TCR-like antibody to CAR, termed TCR-like CAR, will breakthrough the antigen limitation of CAR and combines the benefits of both. Our TCR-like CAR opens therapeutic avenues not only conserving the specificity and the functionality of the original TCR-like antibody, but also performing T cell signaling for cellular functions.

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DESCRIPTION

  • Target
  • NY-ESO-1
  • Targeting Cell Type
  • T Cell
  • Receptor Construction
  • scFv-CD28-CD3ζ
  • Discription of Signaling Cassetes
  • CD28
    CD28 (Cluster of Differentiation 28) is one of the proteins expressed on T cells that provide costimulatory signals required for T cell activation and survival. CD28 is the receptor for CD80 (B7.1) and CD86 (B7.2) proteins which are expressed on antigen-presenting cells (APC). CD28 modulates the primary TCR/CD3ζ signal in a different fashion than the late costimulatory elements OX40 and 4-1BB. CD28 enhances the expression of downstream regulators that impact on T-cell proliferation, death, differentiation, and effector functions. CAR+ T cells containing the CD28 endodomain showed strikingly enhanced sustained T cell activation, growth, survival. And CD28 results in a brightly expressed, stable receptor as the transmembrane domain. Including CD28 costimulatory domains in CARs led to enhanced anti-malignancy efficacy.
    CD3ζ
    CD3ζ, also known as T-cell receptor zeta, which together with T-cell receptor and CD3γ, δ , ε chain, forms the TCR-CD3 complex. ζ was expressed independently from the complex. The zeta chain plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. CD3-zeta, which contains 3 ITAMs, is the most commonly used endodomain component of CARs. It transmits an activation signal to the T cell after antigen is bound. CD3-zeta may not provide a fully competent activation signal and additional co-stimulatory signaling is needed. For example, chimeric CD28 and OX40 can be used with CD3-zeta to transmit a proliferative/survival signal, or all three can be used together.
  • Vector Name
  • pCDCAR1
  • Vector Type
  • Lentiviral vector
  • Epitope
  • SLIMWITQC
  • HLA
  • HLA-A*0201
  • Targeting Diseases
  • scFv-CD28-CD3ζ

BACKGROUND

  • Clone
  • 3M4F4
  • Host
  • Human
  • Target Species
  • Human
  • Synonyms
  • CTAG; ESO1; CT6.1; CTAG1; LAGE-2; LAGE2B; NY-ESO-1

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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