Automated Protein Synthesis & Screening Service

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Are you facing challenges with prolonged drug discovery timelines, complicated protein production, or the intricacies of antibody generation and clinical trials? We provide an advanced automated protein synthesis and screening solution that delivers exceptional results. We utilize advanced recombinant DNA technology and bioprinting systems to provide superior proteins and expedite your research efforts.

Background

The landscape of drug discovery necessitates transformative progress in the realms of protein expression and production. Conventional approaches frequently experience issues with low throughput, restricted scalability, and difficulties in the expression of complex proteins. Effective platforms are necessary to expedite the research process in drug discovery. Automation enables the evaluation of complicated recombinant proteins quickly and comprehensively. Identification of pharmacological targets, the evolution of treatments, and the understanding of biological processes all depend critically on effective protein synthesis and screening. Automated systems help researchers to efficiently overcome bottlenecks, thus enabling the investigation of more protein variations and situations, so accelerating and more successful research output.

Fig.1 Cell-free protein synthesis.¹

Automated Protein Synthesis and Screening Service at Creative Biolabs

Creative Biolabs' automated protein synthesis and screening service provides comprehensive solutions to accelerate your research. We offer a streamlined workflow designed to deliver high-quality proteins efficiently. This encompasses a range of integrated services and advanced technologies aimed at optimizing every stage of protein production, from initial gene design to final protein purification and analysis. Our approach is tailored to meet the diverse needs of our clients, whether they are involved in early-stage research, drug discovery, or biopharmaceutical development. By leveraging automation-bioprinting, we not only accelerate the pace of research but also enhance the reproducibility and reliability of results, ensuring that our clients receive the highest quality proteins for their specific applications. This efficiency translates to significant time and cost savings, allowing researchers to focus on other critical aspects of their work and ultimately expediting the path to new discoveries and therapeutic breakthroughs.

Our Workflow

Step 1

Genetic Construct Engineering

Rational codon optimization and modular vector architecture ensure precise transcriptional regulation for enhanced recombinant protein yields.

Step 2

Parallelized Biosynthesis

Cell-free expression systems enable rapid, scalable production of diverse polypeptides through in vitro transcription-translation workflows.

Step 3

Biophysical Parameterization

High-content screening of temperature gradients, induction kinetics, and redox conditions identifies empirically validated expression regimes.

Step 4

Bioactivity Verification

Affinity-based purification paired with orthogonal analytical techniques (SEC-MALS, SPR) confirms structural integrity and functional specificity.

Step 5

Industrial Translation (On Demand)

Seamless transition to perfusion bioreactor systems guarantees batch-to-batch consistency for therapeutic-grade biologics.

Service Highlights

Speed: Rapidly synthesize and screen proteins, significantly reducing development time.
Efficiency: High-throughput capabilities allow for the simultaneous analysis of multiple protein constructs and conditions.
Quality: Obtain high-quality, functional proteins for downstream applications.
Cost-Effectiveness: Reduce overall costs associated with protein production and analysis.

FAQs

Q1: What biomolecular targets are compatible with your synthesis and screening platform?

A1: Our platform supports the production and functional characterization of a broad spectrum of biomolecular targets, including engineered recombinant proteins, monoclonal antibodies, and catalytic enzymes. Specifications such as structural domains, post-translational modifications, or activity assays can be tailored to experimental objectives upon request.

Q2: What is the temporal scope for project completion?

A2: Processing durations span 14-42 days, with temporal resolution determined by experimental parameters including target complexity, screening throughput, and analytical validation requirements.

Q3: What purity benchmarks are maintained in your workflows?

A3: We deliver ultrahigh purity grades (>95% by orthogonal analytical methods), ensuring batch-to-batch reproducibility for structural and functional studies. Technical documentation detailing endotoxin levels, aggregation profiles, and chromatographic validation is available upon inquiry.

Q4: Can you handle large-scale protein production?

A4: We provide services for scaling up to accommodate larger quantities of protein.

Work with Creative Biolabs

Creative Biolabs pioneers advancements in protein characterization and therapeutic development through its integrated automated synthesis and high-throughput screening platforms. These systems, supported by domain-specific expertise and validated analytical frameworks, enable reproducible production of structurally defined proteins and generation of functionally annotated datasets. Reach out to us to discover how our knowledge can advance your project.

Reference

Yue, Ke, et al. "Advancing synthetic biology through cell-free protein synthesis." Computational and structural biotechnology journal 21 (2023): 2899-2908. Distributed under Open Access License CC BY 4.0, without modification.

All products and services are For Research Use Only and CANNOT be used in the treatment or diagnosis of disease.