The vector of switchable chimeric antigen receptor (CAR) is constructed for the engineering of T cells to target human CD19. The T cells are genetically modified through transduction with a lentiviral vector expressing K4 epitope linked to 4-1BB (CD137) and CD3ζ signaling domains. By using E4 epitope-tagged anti-CD19 antibody Fab, the interaction of E4/K4 will lead to the functioning of CAR-modified T cells. And the vector product was designed for the treatment of chronic lymphocytic leukemia.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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