The vector of anti-HLA-A2 chimeric antigen receptor (CAR) is constructed for the engineering of T cells to target human HLA-A2. The T cells are genetically modified through transduction with a lentiviral vector expressing scFv of anti-HLA-A2 antibody linked to CD3ζ signaling domains. And the vector product was designed for the treatment of Allograft rejection and Graft-versus-host disease (GVHD).
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
|VP-CAR-LC808||Lenti-HLA-A2 CAR (scFv-CD3ζ, BB7.2) Viral Particle|
|CAR-MZ111||Anti-HLA-A2 (BB7.2) h(41BB-CD3ζ) CAR, pCDCAR1|
|CAR-MZ123||Anti-HLA-A2/WT1Db126 (F2) h(CD28- FcγRIγ) CAR, pCDCAR1|
|CAR-MZ124||Anti-HLA-A2/WT1Db126 (F3) h(CD28- FcγRIγ) CAR, pCDCAR1|
|CAR-MZ110||Anti-HLA-A2 (BB7.2) h(CD28-CD3ζ) CAR, pCDCAR1|
|VP-CAR-LC823||Lenti-HLA-A2-WT1Db126 CAR (scFv-FcγRIγ, F3) Viral Particle|
|VP-CAR-LC809||Lenti-HLA-A2 CAR (scFv-CD28-CD3ζ, BB7.2) Viral Particle|
|VP-CAR-LC810||Lenti-HLA-A2 CAR (scFv-41BB-CD3ζ, BB7.2) Viral Particle|
|VP-CAR-LC822||Lenti-HLA-A2-WT1Db126 CAR (scFv-FcγRIγ, F2) Viral Particle|
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