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pCDCAR1 HLAA2/WT1Db126 h(28 FcγRIγ) (CAR-MZ123)

The vector of anti-HLA-A2/WT1Db126 chimeric antigen receptor (CAR) is constructed for the engineering of T cells to target human HLA-A2/WT1Db126. The T cells are genetically modified through transduction with a retroviral vector expressing scFv of anti-HLA-A2/WT1Db126 antibody linked to FcγRIγ signaling domains. And the vector product was designed for the treatment of Human cancers.

Details

  • Target
  • HLA-A2-WT1DB126
  • Target Species
  • Human
  • Targeting Cell Type
  • T cell
  • Targeting Diseases
  • Human cancers
  • Generation
  • First
  • Vector Name
  • pCDCAR1
  • Vector Length
  • ~8kb
  • Vector Type
  • Retroviral
  • Receptor Construction
  • scFv-FcγRIγ
  • Discription of Signaling Cassetes
  • FcγR
    Fc-gamma receptors (FcγR) are Fc receptors (abbreviated FcR) for antibody IgG. All of the Fcγ receptors (FcγR) belong to the immunoglobulin superfamily and are the most important Fc receptors for inducing phagocytosis of opsonized (marked) microbes. This family includes several members, FcγRI (CD64), FcγRIIA (CD32), FcγRIIB (CD32), FcγRIIIA (CD16a), FcγRIIIB (CD16b), which differ in their antibody affinities due to their different molecular structure.
  • Antibody Clone
  • F2
  • Antibody Host
  • Human

Target

  • Gene Name
  • Major Histocompatibility Complex, Class I, A
  • Official Symbol
  • HLA-A
  • Synonyms
  • Major Histocompatibility Complex, Class I, A; HLA Class I Histocompatibility Antigen, A-1 Alpha Chain; HLAA; HLA Class I Histocompatibility Antigen, A-10 Alpha Chain; HLA Class I Histocompatibility Antigen, A-28 Alpha Chain; HLA Class I Histocompatibility Antigen, A-9 Alpha Chain; MHC Class I Antigen HLA-A Heavy Chain; Leukocyte Antigen Class I-A; MHC Class I Antigen A*11; MHC Class I Antigen A*23; MHC Class I Antigen A*24; MHC Class I Antigen A*25; MHC Class I Antigen A*26; MHC Class I Antigen A*29; MHC Class I Antigen A*30; MHC Class I Antigen A*31; MHC Class I Antigen A*32; MHC Class I Antigen A*33; MHC Class I Antigen A*34; MHC Class I Antigen A*36; MHC Class I Antigen A*43

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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