Anti-TEL1 T cell receptor (A6), pCDTCR1(TCR-C245Z)
The vector of anti-TEL1 T cell receptor (TCR) is constructed for the engineering of T cell to target Saccharomyces cerevisiae TEL1. The T cells are genetically modified through transduction with a lentiviral vector expressing TEL1-specific T cell receptor. And the vector product was designed for the treatment of Crohn's disease.
Details
Target Species
Saccharomyces cerevisiae
Targeting Diseases
Crohn's disease
Target
Gene Name
DNA-binding protein kinase TEL1
Synonyms
TEL1; DNA-binding protein kinase TEL1
Introduction
Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]-Q. Recruited by the MRX-complex to sites of DNA lesions immediately after damage to initiate non-homologous end-joining (NHEJ). Subsequently displaced by the RPA complex in a reaction probably involving the SAE2 protein. Phosphorylates MRE11 and XRS2, 2 subunits of the MRX-complex. The phosphorylation of MRE11 is a feedback response from the checkpoint signaling pathway. Phosphorylates RAD9, CHK1 and RAD53, leading to the activation of the CHK1 and RAD23 kinases involved in the DNA damage response cascade. Phosphorylates histone H2A to form H2AS128ph (gamma-H2A) at sites of DNA damage, also involved in the regulation of DNA damage response mechanism. Phosphorylates also SLX4 and RTT107 which are involved in genome stability. Required for the control of telomere length and genome stability.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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