Lenti-CD138 CAR (scFv-28ζ)-VP(VP-CAR-LC654)

The ready-to-use lentiviral particles of Lenti-CD138 CAR (scFv-28ζ)-VP is packaged using 3rd generation of lentiviral packaging system, in which the gene of CAR will be driven by a CMV promotor. The target gene of scFv-CD28-CD3ζ packaged in lentiviral particles could be used for high efficency tranduction of T cells and stably integrated expression.


Specifications


Type of Therapeutics
Chimeric Antigen Receptor
Target
CD138
Expression Cassette
scFv-CD28-CD3ζ
Promotor
CMV
Packaging System
Lentivirus
Packaging Cell
293T
Targeting Diseases
Multiple myeloma

Target


Introduction
The protein encoded by this gene is a transmembrane (type I) heparan sulfate proteoglycan and is a member of the syndecan proteoglycan family. The syndecans mediate cell binding, cell signaling, and cytoskeletal organization and syndecan receptors are required for internalization of the HIV-1 tat protein. The syndecan-1 protein functions as an integral membrane protein and participates in cell proliferation, cell migration and cell-matrix interactions via its receptor for extracellular matrix proteins. Altered syndecan-1 expression has been detected in several different tumor types. While several transcript variants may exist for this gene, the full-length natures of only two have been described to date. These two represent the major variants of this gene and encode the same protein.
Alternative Names
SDC; CD138; SYND1; syndecan
Gene ID

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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CONTACT US

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Tel: 1-631-871-5806
Fax: 1-631-207-8356
Email:

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Tel: 44-207-048-3343

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