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Lenti-EGP-2 CAR (scFv-BBζ, GA733.2)-VP(VP-CAR-LC217)

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The ready-to-use lentiviral particles of Lenti-EGP-2 CAR (scFv-BBζ, GA733.2)-VP is packaged using 3rd generation of lentiviral packaging system, in which the gene of CAR will be driven by a CMV promotor. The target gene of scFv (GA733.2)-41BB-CD3ζ packaged in lentiviral particles could be used for high efficency tranduction of T cells and stably integrated expression.

Specifications

Type of Therapeutics
Chimeric Antigen Receptor
Target
EGP-2
Expression Cassette
scFv (GA733.2)-41BB-CD3ζ
Clone
GA733.2
Promotor
CMV
Packaging System
Lentivirus
Packaging Cell
293T
Targeting Diseases
EGP-2+ colon cancer

Target

Introduction
This gene encodes a carcinoma-associated antigen and is a member of a family that includes at least two type I membrane proteins. This antigen is expressed on most normal epithelial cells and gastrointestinal carcinomas and functions as a homotypic calcium-independent cell adhesion molecule. The antigen is being used as a target for immunotherapy treatment of human carcinomas. Mutations in this gene result in congenital tufting enteropathy. [provided by RefSeq, Dec 2008]
Alternative Names
EPCAM; epithelial cell adhesion molecule; ESA; KSA; M4S1; MK-1; DIAR5; EGP-2; EGP40; KS1/4; MIC18; TROP1; EGP314; HNPCC8; TACSTD1; EGP-2+ colon cancers; colon cancers; scFv; FcεRIγ; Chimeric antigen receptor; T cell; Retrovirus; CARs; Lentivirus; chimeric T cell receptors; chimeric immunoreceptors; chimeric antigen receptors; GA733.2
Gene ID
4072

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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CarcinomaOthers Kits for CARs/TCRs Development 

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USA: 1-631-381-2994
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CONTACT US

USA
45-1 Ramsey Road, Shirley, NY 11967, USA
Tel: 1-631-381-2994
Fax: 1-631-207-8356
Email:

Europe
Ringstrasse 4, 64401 Gross-Bieberau, Germany
Tel: 44-207-097-1828

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