Lenti-ErbB2 CAR (scFv-CD4εRIγ, OTI5C4)-VP(VP-CAR-LC226)

The ready-to-use lentiviral particles of Lenti-ErbB2 CAR (scFv-CD4εRIγ, OTI5C4)-VP is packaged using 3rd generation of lentiviral packaging system, in which the gene of CAR will be driven by a CMV promotor. The target gene of scFv (OTI5C4)-CD4-FcεRIγ packaged in lentiviral particles could be used for high efficency tranduction of T cells and stably integrated expression.


Specifications


Type of Therapeutics
Chimeric Antigen Receptor
Target
ErbB2
Expression Cassette
scFv (OTI5C4)-CD4-FcεRIγ
Clone
OTI5C4
Promotor
CMV
Packaging System
Lentivirus
Packaging Cell
293T
Targeting Diseases
Numerous cancers

Target


Introduction
This gene encodes a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. This protein has no ligand binding domain of its own and therefore cannot bind growth factors. However, it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding and enhancing kinase-mediated activation of downstream signalling pathways, such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase. Allelic variations at amino acid positions 654 and 655 of isoform a (positions 624 and 625 of isoform b) have been reported, with the most common allele, Ile654/Ile655, shown here. Amplification and/or overexpression of this gene has been reported in numerous cancers, including breast and ovarian tumors. Alternative splicing results in several additional transcript variants, some encoding different isoforms and others that have not been fully characterized.
Alternative Names
NEU; NGL; HER2; TKR1; CD340; HER-2; MLN 19; HER-2/neu
Gene ID

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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CONTACT US

USA
45-1 Ramsey Road, Shirley, NY 11967, USA
Tel: 1-631-381-2994
Fax: 1-631-207-8356
Email:

Europe
Tel: 44-207-097-1828

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