Lenti-FRB CAR (scFv-28ζ, m909)-VP(VP-CAR-LC650)

The ready-to-use lentiviral particles of Lenti-FRB CAR (scFv-28ζ, m909)-VP is packaged using 3rd generation of lentiviral packaging system, in which the gene of CAR will be driven by a CMV promotor. The target gene of scFv (m909)-CD28-CD3ζ packaged in lentiviral particles could be used for high efficency tranduction of T cells and stably integrated expression.


Specifications


Type of Therapeutics
Chimeric Antigen Receptor
Target
FRβ (Folate receptor-beta)
Expression Cassette
scFv (m909)-CD28-CD3ζ
Clone
m909
Promotor
CMV
Packaging System
Lentivirus
Packaging Cell
293T
Targeting Diseases
Acute myeloid leukemia

Target


Introduction
The protein encoded by this gene is a member of the folate receptor (FOLR) family, and these genes exist in a cluster on chromosome 11. Members of this gene family have a high affinity for folic acid and for several reduced folic acid derivatives, and they mediate delivery of 5-methyltetrahydrofolate to the interior of cells. This protein has a 68% and 79% sequence homology with the FOLR1 and FOLR3 proteins, respectively. Although this protein was originally thought to be specific to placenta, it can also exist in other tissues, and it may play a role in the transport of methotrexate in synovial macrophages in rheumatoid arthritis patients. Multiple transcript variants that encode the same protein have been found for this gene.
Alternative Names
FOLR2; Folate receptor beta; FBP; FR-P3; FR-BETA; BETA-HFR; FBP/PL-1
Gene ID

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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Leukemia

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Tel: 1-631-871-5806
Fax: 1-631-207-8356
Email:

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Tel: 44-207-048-3343

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