Lenti-Mesothelin CAR (scFv-BBζ, M3)-VP(VP-CAR-LC557)

The ready-to-use lentiviral particles of Lenti-Mesothelin CAR (scFv-BBζ, M3)-VP is packaged using 3rd generation of lentiviral packaging system, in which the gene of CAR will be driven by a CMV promotor. The target gene of scFv (M3)-41BB-CD3ζ packaged in lentiviral particles could be used for high efficency tranduction of T cells and stably integrated expression.


Specifications


Type of Therapeutics
Chimeric Antigen Receptor
Target
Mesothelin
Expression Cassette
scFv (M3)-41BB-CD3ζ
Clone
M3
Promotor
CMV
Packaging System
Lentivirus
Packaging Cell
293T
Targeting Diseases
Pancreatic cancer, Ovarian cancer, Lung cancer, Malignant pleural mesothelioma tumors (MPM tumors)

Target


Introduction
This gene encodes a precursor protein that is cleaved into two products, megakaryocyte potentiating factor and mesothelin. Megakaryocyte potentiation factor functions as a cytokine that can stimulate colony formation in bone marrow megakaryocytes. Mesothelian is a glycosylphosphatidylinositol-anchored cell-surface protein that may function as a cell adhesion protein. This protein is overexpressed in epithelial mesotheliomas, ovarian cancers and in specific squamous cell carcinomas. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Apr 2010]
Alternative Names
MSLN; mesothelin; MPF; SMRP; pancreatic cancer; ovarian cancer; lung cancer; malignant pleural mesothelioma tumors; MPM tumors; scFv; FcεRIγ; Chimeric antigen receptor; T cell; Retrovirus; CARs; Lentivirus; chimeric T cell receptors; chimeric immunoreceptors; chimeric antigen receptors; SS1
Gene ID

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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Tel: 1-631-871-5806
Fax: 1-631-207-8356
Email:

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