Lenti-TSLPR CAR (scFv-CD8BBζ, 3G11)-VP(VP-CAR-LC802)

The ready-to-use lentiviral particles of Lenti-TSLPR CAR (scFv-CD8BBζ, 3G11)-VP is packaged using 3rd generation of lentiviral packaging system, in which the gene of CAR will be driven by a CMV promotor. The target gene of scFv (3G11)-CD8-41BB-CD3ζ packaged in lentiviral particles could be used for high efficency tranduction of T cells and stably integrated expression.


Specifications


Type of Therapeutics
Chimeric Antigen Receptor
Target
TSLPR
Expression Cassette
scFv (3G11)-CD8-41BB-CD3ζ
Clone
3G11
Promotor
CMV
Packaging System
Lentivirus
Packaging Cell
293T
Targeting Diseases
B-lineage acute lymphoblastic leukemia (B-ALL)

Target


Introduction
This gene encodes a member of the type I cytokine receptor family. The encoded protein is a receptor for thymic stromal lymphopoietin (TSLP). Together with the interleukin 7 receptor (IL7R), the encoded protein and TSLP activate STAT3, STAT5, and JAK2 pathways, which control processes such as cell proliferation and development of the hematopoietic system. Rearrangement of this gene with immunoglobulin heavy chain gene (IGH) on chromosome 14, or with P2Y purinoceptor 8 gene (P2RY8) on the same X or Y chromosomes is associated with B-progenitor acute lymphoblastic leukemia (ALL) and Down syndrome ALL. Alternatively spliced transcript variants have been found for this gene.
Alternative Names
CRLF2; cytokine receptor-like factor 2; CRL2; TSLPR; CRLF2Y; IL-XR; TSLP receptor; cytokine receptor CRL2 precusor; thymic stromal lymphopoietin protein receptor; thymic stromal-derived lymphopoietin receptor; anti-TSLPR
Gene ID

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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Leukemia

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Tel: 1-631-871-5806
Fax: 1-631-207-8356
Email:

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Tel: 44-207-048-3343

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