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LentiStable™ Inducible Stable PCL Platform for Lentivirus Production

All products and services are For Research Use Only and CANNOT be used in the treatment or diagnosis of disease.

Lentiviral vectors (LV) represent a key tool for gene and cell therapy applications. However, the production of these vectors is plasmid supply-dependent and cannot be directly expanded. The production of sufficient quantities of viral products for clinical applications remains an obstacle and has prompted the development of suspension processes in this field that are conducive to mass production.

At Creative Biolabs, we use an inducible system to avoid cell death due to the continuous expression of cytotoxic proteins (Gag, Rev, and VSV-G), thereby developing a highly efficient LentiStable™ inducing stable PCL platform. The LV packaging cell line can stably integrate certain components of the lentiviral system into the cell genome, thereby achieving scalable and cost-effective manufacturing.

From packaging to producer cell lines

We have generated suspension and adherent-based stable packaging and producer cell lines using an inducible system. The packaging cell line stably integrates certain components of the lentiviral system into the cell genome (envelope (e.g. VSV-G), Gag/Pol and Rev), while the production cell line integrates all components (envelope (e.g. VSV-G), Gag/Pol, Rev, and Vector Genome). Since this process does not require helper viruses, expensive transfection reagents, or cGMP-grade plasmids, it can achieve stable high-quality virus delivery, cost-effective manufacturing, and minimize process risks.

Schematic for lentiviral vector production in an inducible packaging cell line. Fig.1 Schematic for lentiviral vector production in an inducible packaging cell line.

Advantages of our LentiStable™ Platform

LentiStable™ Inducible Stable PCL Platform for Lentivirus Production

STABLE PRODUCER CELLS

All components produced by LV are stably integrated into one producer cell line

LentiStable™ Inducible Stable PCL Platform for Lentivirus Production

FULLY SCALABLE

Scale up from shake flasks to large bioreactors without reducing productivity

LentiStable™ Inducible Stable PCL Platform for Lentivirus Production

ROBUST PROCESS

Reliably produce LV in suspension bioreactors and serum-free media

LentiStable™ Inducible Stable PCL Platform for Lentivirus Production

CONSISTENT QUALITY

Consistent LV quality from batch to batch-no transfection step

If you are interested in our services, please send an email to contact us, and our team will get back to you as soon as possible.

All products and services are For Research Use Only and CANNOT be used in the treatment or diagnosis of disease.

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All products and services are For Research Use Only and CANNOT be used in the treatment or diagnosis of disease.

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