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pCDCAR1 Mesothelin h(CD3ζ)(CAR-LC176)

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The vector of anti-mesothelin chimeric antigen receptor (CAR) is constructed for the engineering of T cells to target human mesothelin. The T cells are genetically modified through transduction with a lentiviral vector expressing scFv of anti-mesothelin antibody linked to CD3ζ signaling domain. And the vector product was designed for the treatment of pancreatic cancer, ovarian cancer, lung cancer, malignant pleural mesothelioma tumors (MPM tumors).

Details

Target
Mesothelin
Target Species
Human
Targeting Cell Type
T cell
Targeting Diseases
Pancreatic cancer, Ovarian cancer, Lung cancer, Malignant pleural mesothelioma tumors (MPM tumors)
Generation
First
Vector Name
pCDCAR1
Vector Length
~8kb
Vector Type
Lentiviral
Receptor Construction
scFv-CD3ζ
Discription of Signaling Cassetes
CD3ζ
CD3ζ, also known as T-cell receptor zeta, which together with T-cell receptor and CD3γ, δ , ε chain, forms the TCR-CD3 complex. ζ was expressed independently from the complex. The zeta chain plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. CD3-zeta, which contains 3 ITAMs, is the most commonly used endodomain component of CARs. It transmits an activation signal to the T cell after antigen is bound. CD3-zeta may not provide a fully competent activation signal and additional co-stimulatory signaling is needed. For example, chimeric CD28 and OX40 can be used with CD3-zeta to transmit a proliferative/survival signal, or all three can be used together.
Antibody Clone
P4
Antibody Host
Human

Target

Gene Name
mesothelin
Official Symbol
MSLN
Gene ID
10232
Synonyms
MSLN; mesothelin; MPF; SMRP; pancreatic cancer; ovarian cancer; lung cancer; malignant pleural mesothelioma tumors; MPM tumors; scFv; FcεRIγ; Chimeric antigen receptor; T cell; Retrovirus; CARs; Lentivirus; chimeric T cell receptors; chimeric immunoreceptors; chimeric antigen receptors; SS1

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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Germ Cell TumorCarcinoma Kits for CARs/TCRs Development 

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USA
45-1 Ramsey Road, Shirley, NY 11967, USA
Tel: 1-631-381-2994
Fax: 1-631-207-8356
Email:

Europe
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Tel: 44-207-097-1828

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