Anti-RPS4Y T cell receptor (YKIII.8), pCDTCR1(TCR-C225Z)

The vector of anti-RPS4Y T cell receptor (TCR) is constructed for the engineering of T cell to target Human RPS4Y. The T cells are genetically modified through transduction with a lentiviral vector expressing RPS4Y-specific T cell receptor. And the vector product was designed for the treatment of Graft versus host disease (GvHD).


Details


Target
RPS4Y
Target Species
Human
Epitope
TIRYPDPVI
Format
Non-modified
HLA
HLA-B*5201
Targeting Diseases
Graft versus host disease (GvHD)
Vector Name
pCDTCR1
Vector Length
~8kb
Vector Type
Lentiviral
Antibody Clone
YKIII.8
Antibody Host
Mouse

Target


Gene Name
ribosomal protein S4, Y-linked 1
Official Symbol
RPS4Y1
Gene ID
UniProt ID
Synonyms
RPS4Y1; ribosomal protein S4, Y-linked 1; S4; RPS4Y
Introduction
Cytoplasmic ribosomes, organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes ribosomal protein S4, a component of the 40S subunit. Ribosomal protein S4 is the only ribosomal protein known to be encoded by more than one gene, namely this gene and ribosomal protein S4, X-linked (RPS4X). The 2 isoforms encoded by these genes are not identical, but are functionally equivalent. Ribosomal protein S4 belongs to the S4E family of ribosomal proteins. It has been suggested that haploinsufficiency of the ribosomal protein S4 genes plays a role in Turner syndrome; however, this hypothesis is controversial. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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