The vector of anti-mesothelin chimeric antigen receptor (CAR) is constructed for the engineering of T cells to target human mesothelin. The T cells are genetically modified through transduction with a lentiviral vector expressing scFv of anti-mesothelin antibody, two CD137 (4-1BB) signaling domains, an FKBP and FRB dimerizer-binding pair, and a CD3-zeta signaling domain. The activation of conditional CAR can be controlled by FKBP-FRB dimerization using rapamycin. And the vector product was designed for the treatment of pancreatic cancer, ovarian cancer, lung cancer, malignant pleural mesothelioma tumors (MPM tumors).
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
|CAR-LC067||Anti-Mesothelin (M2) h(41BB-CD3ζ) CAR, pCDCAR1|
|VP-CAR-LC565||Lenti-Mesothelin CAR (scFv-41BB-CD3ζ, M11) Viral Particle|
|CAR-LC074||Anti-Mesothelin (M9) h(41BB-CD3ζ) CAR, pCDCAR1|
|VP-CAR-LC357||Lenti-Mesothelin CAR (scFv-CD28-CD3ζ, SS1) Viral Particle|
|CAR-LC089||Anti-Mesothelin (M24) h(41BB-CD3ζ) CAR, pCDCAR1|
|VP-CAR-LC356||Lenti-Mesothelin CAR (scFv-CD28-FcεRIγ, SS1) Viral Particle|
|VP-CAR-LC559||Lenti-Mesothelin CAR (scFv-41BB-CD3ζ, M5) Viral Particle|
|VP-CAR-LC544||Lenti-Mesothelin CAR (scFv-CD28-41BB-CD3ζ, HN1) Viral Particle|
|CAR-LC086||Anti-Mesothelin (M21) h(41BB-CD3ζ) CAR, pCDCAR1|
|VP-CAR-LC562||Lenti-Mesothelin CAR (scFv-41BB-CD3ζ, M8) Viral Particle|
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