pCDCAR1 MUC16 h(CD137ζ)(CAR-MZ120)

The vector of anti-MUC16 chimeric antigen receptor (CAR) is constructed for the engineering of T cells to target human MUC16. The T cells are genetically modified through transduction with a lentiviral vector expressing scFv of anti-MUC16 antibody linked to CD137 and CD3ζ signaling domains. And the vector product was designed for the treatment of Ovarian cancer.


Details


Target
MUC16
Target Species
Human
Targeting Cell Type
T cell
Targeting Diseases
Ovarian cancer
Generation
Second
Vector Name
pCDCAR1
Vector Length
~8kb
Vector Type
Lentiviral
Receptor Construction
scFv-CD137-CD3ζ
Discription of Signaling Cassetes
CD137
CD137 is a member of the tumor necrosis factor (TNF) receptor family. Its alternative names are tumor necrosis factor receptor superfamily member 9 (TNFRSF9), 4-1BB and induced by lymphocyte activation (ILA). It is currently of interest to immunologists as a co-stimulatory immune checkpoint molecule. CD137 can be expressed by activated T cells, but to a larger extent on CD8 than on CD4 T cells. In addition, CD137 expression is found on dendritic cells, B cells, follicular dendritic cells, natural killer cells, granulocytes and cells of blood vessel walls at sites of inflammation.
CD3ζ
CD3ζ, also known as T-cell receptor zeta, which together with T-cell receptor and CD3γ, δ , ε chain, forms the TCR-CD3 complex. ζ was expressed independently from the complex. The zeta chain plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. CD3-zeta, which contains 3 ITAMs, is the most commonly used endodomain component of CARs. It transmits an activation signal to the T cell after antigen is bound. CD3-zeta may not provide a fully competent activation signal and additional co-stimulatory signaling is needed. For example, chimeric CD28 and OX40 can be used with CD3-zeta to transmit a proliferative/survival signal, or all three can be used together.
Antibody Clone
4H11
Antibody Host
Mouse

Target


Gene Name
mucin 16, cell surface associated
Official Symbol
MUC16
Gene ID
Synonyms
MUC16; mucin 16; cell surface associated; CA125; mucin-16; CA125 ovarian cancer antigen; ovarian carcinoma antigen CA125; ovarian cancer-related tumor marker CA125; RP215

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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