OAd5Δ55-pSP-B/RGD4C-ITGB3, VP(OAdVP-TMM3491)

This product is an cytokine-armed oncolytic adenovirus which is driven by promoter SP-B. The virus is characterized by a 55k deletion in E1B and RGD-4C-modified capsid. This ITGB3-expressing OAd Virus can selectively replicate in and kill tumor cell.


BACKGROUND


Adenoviruses have long been a popular viral vector for gene therapy due to their ability to affect both replicating and non-replicating cells, accommodate large transgenes, and code for proteins without integrating into the host cell genome. Oncolytic adenoviruses are genetically manipulated human adenoviruses that acquired a replication phenotype in tumor cells, but show a more restricted phenotype in normal cells.

Virus Backbone


Family
Adenoviridae
Species
Human adenovirus C
Serotype
Human adenovirus C type 5

Features of Construction


Family
Adenoviridae
Promoter
SP-B
Gene Modification
E1BΔ55k
Capsid Modification
RGD-4C
Type of Transgene
Cytokine

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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Oncolytic VirusLeukemia

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CONTACT US

USA
45-1 Ramsey Road, Shirley, NY 11967, USA
Tel: 1-631-871-5806
Fax: 1-631-207-8356
Email:

Europe
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Tel: 44-207-097-1828

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