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pCDCAR1 C2 m(γ), T (CAR-T-1-M304-G)

The vector of anti-C2γ and C2ζ chimeric antigen receptor (CAR) is constructed for the engineering of T cells to target mouse C2γ and C2ζ. The T cells are genetically modified through transduction with a lentiviral vector expressing scFv of anti-C2γ and C2ζ antibody linked to FcεRIγ signaling domains. And the vector product was designed for the treatment of autoimmune arthritis.

Details

  • Target
  • C2
  • Target Species
  • Mouse
  • Targeting Cell Type
  • T cell
  • Targeting Diseases
  • Autoimmune arthritis
  • Generation
  • First
  • Vector Name
  • pCDCAR1
  • Vector Length
  • 8kb
  • Vector Type
  • Lentiviral
  • Receptor Construction
  • scFv-FcεRIγ
  • Discription of Signaling Cassetes
  • FcεRIγ
    The high-affinity IgE receptor, also known as FcεRI, or Fc epsilon RI, is the high-affinity receptor for the Fc region of immunoglobulin E (IgE). FcεRI is a key molecule involved in allergic reactions. It is a tetramer composed of 1alpha, 1 beta, and 2 gamma chains. The gamma chains are also subunits of other Fc receptors. The scFv-based CARs engineered to contain a signaling domain from FcεRIγ have been shown to deliver a potent signal for T cell activation and function.
  • Antibody Clone
  • CIIC1; M2139
  • Antibody Host
  • Mouse

Target

  • Gene Name
  • type II collagen
  • Official Symbol
  • C2
  • Synonyms
  • C2; type II collagen; autoimmune arthritis; arthritis; scFv; FcεRIγ; Chimeric antigen receptor; T cell; Retrovirus; CARs; Lentivirus; chimeric T cell receptors; chimeric immunoreceptors; chimeric antigen receptors; CIIC1; M2139;CIIC1; M2139

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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