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The vector of anti-CD30 chimeric antigen receptor (CAR) is constructed for the engineering of T cells to target Human CD30. The T cells are genetically modified through transduction with a lentiviral vector expressing scFv of anti-CD30 antibody linked to 41BB and CD3ζ signaling domains. And the vector product was designed for the treatment of Hodgkin lymphomas.
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CAR Construction : T105 scFv-41BB-CD28ζ
Fig.1 Flow cytometry. Representative plot of T cells transduced at day 2 with CD30-CAR-encoding lentivirus and CD30-CAR expression and analysed by flow cytometry using an anti-CD3 and anti-EGFRt antibodies. Alvarez-Fernández, C., Escribà-Garcia, L., Caballero, A. C., Escudero-López, E., Ujaldón-Miró, C., Montserrat-Torres, R., Pujol-Fernández, P., Sierra, J., & Briones, J. (2021). Memory stem T cells modified with a redesigned CD30-chimeric antigen receptor show an enhanced antitumor effect in Hodgkin lymphoma. Clinical & translational immunology, 10(4), e1268. |
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CAR Construction : T105 scFv-41BB-CD28ζ
Fig.1 CD30-CAR TSCM-like enriched culture efficiently eradicates HL in vitro. Cytokine secretion of CD30-CAR TSCM-like enriched culture (n = 3) 24 h after L540, L428 and Raji co-culture. Untransduced TSCM-like cells were used as negative control. Cytokine levels of IL-2, IL-6, IL-10, IFN-γ and TNF-α were measured by cytometry-based multiplex analysis (mean ± SD). Alvarez-Fernández, C., Escribà-Garcia, L., Caballero, A. C., Escudero-López, E., Ujaldón-Miró, C., Montserrat-Torres, R., Pujol-Fernández, P., Sierra, J., & Briones, J. (2021). Memory stem T cells modified with a redesigned CD30-chimeric antigen receptor show an enhanced antitumor effect in Hodgkin lymphoma. Clinical & translational immunology, 10(4), e1268. |
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