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pCDCAR1 CD56 h(28), T (CAR-T-1-M312-2)

The vector of anti-CD56 chimeric antigen receptor (CAR) is constructed for the engineering of T cells to target human CD56. The T cells are genetically modified through transduction with a lentiviral vector expressing scFv of anti-CD56 antibody linked to CD28 signaling domains. And the vector product was designed for the treatment of relapsed refractory myeloma.

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Details

  • Target
  • CD56
  • Targeting Cell Type
  • T cell
  • Targeting Diseases
  • Relapsed refractory myeloma
  • Generation
  • First
  • Vector Name
  • pCDCAR1
  • Vector Length
  • 8kb
  • Vector Type
  • Lentiviral
  • Receptor Construction
  • scFv-CD28
  • Discription of Signaling Cassetes
  • CD28
    CD28 (Cluster of Differentiation 28) is one of the proteins expressed on T cells that provide co-stimulatorysignals required for T cell activation and survival. CD28 is the receptor for CD80 (B7.1) and CD86 (B7.2) proteins which are expressed on antigen-presenting cells(APC). CD28 modulates the primary TCR/CD3ζ signal in a different fashion than the late costimulatory elements OX40 and 4-1BB. CD28 enhances the expression of downstream regulators that impact on T-cell proliferation, death, differentiation, and effector functions. CAR+ T cells containing the CD28 endodomain showed strikingly enhanced sustained T cell activation, growth, survival. And CD28 results in a brightly expressed, stable receptor as the transmembrane domain. Including CD28 costimulatory domains in CARs led to enhanced anti-malignancy efficacy.

Target

  • Clone
  • N901
  • Host
  • Mouse
  • Target Species
  • Human
  • Gene Name
  • Neural Cell Adhesion Molecule 1
  • Synonyms
  • Neural Cell Adhesion Molecule 1; NCAM; Antigen Recognized By Monoclonal Antibody 5.1H11; Neural Cell Adhesion Molecule, NCAM; CD56 Antigen; N-CAM-1; NCAM-1; MSK39; CD56

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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