The vector of anti-CD70 chimeric antigen receptor (CAR) is constructed for the engineering of T cells to target human CD70. The T cells are genetically modified through transduction with a lentiviral vector expressing the full-length CD70 receptor (CD27) linked to FcεRIγ signaling domains. And the vector product was designed for the immunotherapy of chronic lymphocytic leukemia (CLL).
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
|CAR-LC293||Anti-CD70 h(CD3ζ) Ligand-based CAR, pCDCAR1|
|CAR-T-2-L405-CZ||CD70 h(b2c-CD3ζ) CAR, [T]|
|CAR-T-1-L405-Z||CD70 h(CD3ζ) CAR, [T]|
|CAR-T-2-L405-4Z||CD70 h(CD4-CD3ζ) CAR, [T]|
|CAR-T-2-L405-2Z||CD70 h(CD28-CD3ζ) CAR, [T]|
|CAR-T-3-L405-2BZ||CD70 h(CD28-41BB-CD3ζ) CAR, [T]|
|CAR-T-3-L405-2XZ||CD70 h(CD28-OX40-CD3ζ) CAR, [T]|
|CAR-T-2-L405-BZ||CD70 h(41BB-CD3ζ) CAR, [T]|
|CAR-T-1-L405-2||CD70 h(CD28) CAR, [T]|
|CAR-T-2-L405-2G||CD70 h(CD28-FcεRIγ) CAR, [T]|
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