Close

pCDCAR1 GD2 h(γ), NK (CAR-NK-1-M330-G)

The vector of anti-GD2 chimeric antigen receptor(CAR) is constructed for the engineering of NK cells to target Human GD2. The NK cells are genetically modified through transduction with a lentiviral vector expressing scFv of anti-GD2 antibody linked to FcεRIγ signaling domains. And the vector product was designed for the treatment of neuroblastoma and melanoma.

Datasheet   Add to Cart

Details

  • Target
  • GD2
  • Targeting Cell Type
  • NK cell
  • Targeting Diseases
  • Neuroblastoma; melanoma
  • Generation
  • First
  • Vector Name
  • pCDCAR1
  • Vector Length
  • 8kb
  • Vector Type
  • Lentiviral
  • Receptor Construction
  • scFv-FcεRIγ
  • Discription of Signaling Cassetes
  • FcεRIγ
    The high-affinity IgE receptor, also known as FcεRI, or Fc epsilon RI, is the high-affinity receptor for the Fc region of immunoglobulin E (IgE). FcεRI is a key molecule involved in allergic reactions. It is a tetramer composed of 1alpha, 1 beta, and 2 gamma chains. The gamma chains are also subunits of other Fc receptors. The scFv-based CARs engineered to contain a signaling domain from FcεRIγ have been shown to deliver a potent signal for T cell activation and function.

Target

  • Clone
  • ch14.18
  • Host
  • Chimeric
  • Target Species
  • Human
  • Gene Name
  • beta-1,4-N-acetyl-galactosaminyltransferase 1
  • Synonyms
  • GALGT; SPG26; GALNACT; GalNAc-T

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

Related Products

All services and products are only for lab research use, not for any clinical diagnosis or treatment.

Online Inquiry

For any technical issues or products/services related questions, please leave your information below. Our team will contact you soon.

  • Verification code
    Click image to refresh the verification code.

Key Updates

Receive our latest news and insights.