pCDCAR1 MUC1 h(γ), T(CAR-T-1-M553-G)

The vector of anti-MUC1 chimeric antigen receptor(CAR) is constructed for the engineering of T cell to target human MUC1. The T cell is genetically modified through transduction with a lentiviral vector expressing anti-MUC1 VHH linked to FcεRIγ signaling domains. And the vector product was designed for the treatment of breast adenocarcinoma.


Details


Target
MUC1
Target Species
Human
Targeting Cell Type
T cell
Targeting Diseases
Breast adenocarcinoma
Generation
First
Vector Name
pCDCAR1
Vector Length
8kb
Vector Type
Lentiviral
Receptor Construction
VHH-FcεRIγ
Discription of Signaling Cassetes
FcεRIγ
The high-affinity IgE receptor, also known as FcεRI, or Fc epsilon RI, is the high-affinity receptor for the Fc region of immunoglobulin E (IgE). FcεRI is a key molecule involved in allergic reactions. It is a tetramer composed of 1alpha, 1 beta, and 2 gamma chains. The gamma chains are also subunits of other Fc receptors. The scFv-based CARs engineered to contain a signaling domain from FcεRIγ have been shown to deliver a potent signal for T cell activation and function.
Antibody Host
camelid

Target


Gene Name
mucin 1, cell surface associated
Official Symbol
MUC1
Gene ID
4582
Synonyms
MUC1; mucin 1, cell surface associated; EMA; MCD; PEM; PUM; KL-6; MAM6; MCKD; PEMT; CD227; H23AG; MCKD1; MUC-1; ADMCKD; ADMCKD1; CA 15-3; MUC-1/X; MUC1/ZD; MUC-1/SEC; MUC1-expressing tumors; scFv; FcεRIγ; Chimeric antigen receptor; T cell; Retrovirus; CARs; Lentivirus; chimeric T cell receptors; chimeric immunoreceptors; chimeric antigen receptors; HMFG2

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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CONTACT US

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45-1 Ramsey Road, Shirley, NY 11967, USA
Tel: 1-631-871-5806
Fax: 1-631-207-8356
Email:

Europe
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Tel: 44-207-097-1828

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