pCDCAR1 NY-ESO-1 h(BBζ), T(CAR-T-2-M323-BZ)

Datasheet

The vector of anti-NY-ESO-1 chimeric antigen receptor (CAR) is constructed for the engineering of T cells to target human NY-ESO-1. The T cells are genetically modified through transduction with a lentiviral vector expressing scFv of anti-NY-ESO-1 antibody linked to CD137 (4-1BB) and CD3-zeta signaling domains. And the vector product was designed for the treatment of metastatic melanoma and synovial cell sarcoma.

Details

Target

NY-ESO-1

Target Species

Human

Targeting Cell Type

T cell

Targeting Diseases

Metastatic melanoma; synovial cell sarcoma

Generation

Second

Vector Name

pCDCAR1

Vector Length

8kb

Vector Type

Lentiviral

Receptor Construction

scFv-41BB-CD3ζ

Discription of Signaling Cassetes

41BB
CD137 (also known as 4-1BB) is a surface co-stimulatory glycoprotein originally described as present on activated T lymphocytes, which belongs to the tumor necrosis factor (TNF) receptor superfamily. It is expressed mainly on activated CD4+ and CD8+ T cells, and binds to a high-affinity ligand (4-1BBL) expressed on several antigen-presenting cells such as macrophages and activated B cells. On the basis of preclinical observation, this molecule can promote the persistence of antigen-specific and antigen-nonspecific chimeric antigen receptor T-cells to significantly increases antitumor activity.
CD3ζ
CD3ζ, also known as T-cell receptor zeta, which together with T-cell receptor and CD3γ, δ , ε chain, forms the TCR-CD3 complex. ζ was expressed independently from the complex. The zeta chain plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. CD3-zeta, which contains 3 ITAMs, is the most commonly used endodomain component of CARs. It transmits an activation signal to the T cell after antigen is bound. CD3-zeta may not provide a fully competent activation signal and additional co-stimulatory signaling is needed. For example, chimeric CD28 and OX40 can be used with CD3-zeta to transmit a proliferative/survival signal, or all three can be used together.

Antibody Clone

ES121

Antibody Host

Mouse

Target

Gene Name

cancer/testis antigen 1B

Official Symbol

CTAG1B

Gene ID

1485

Synonyms

CTAG1B; cancer/testis antigen 1B; CTAG; ESO1; CT6.1; CTAG1; LAGE-2; LAGE2B; NY-ESO-1; NY-ESO-1–positive tumors; scFv; FcεRIγ; Chimeric antigen receptor; T cell; Retrovirus; CARs; Lentivirus; chimeric T cell receptors; chimeric immunoreceptors; chimeric antigen receptors; ES121

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

Related Products

Cat#	Description
TCR-L156	Human anti-NY-ESO-1 T cell receptor (TCRCD8-NY#13), pCDTCR1
CAR-T-2-M323-4Z	Anti-NY-ESO-1 scFv h(CD4-CD3ζ) CART, pCDCAR1
VP-TCR-C058	Lenti-NY-ESO-1 T cell receptor (TCRCD8-NY#8) Viral Particle
TCR-L162	Human anti-NY-ESO-1 T cell receptor (TCRCD4-NY#10), pCDTCR1
VP-TCR-C073	Lenti-NY-ESO-1 T cell receptor (5B8) Viral Particle
VP-TCR-C063	Lenti-NY-ESO-1 T cell receptor (TCRCD4-NY#3) Viral Particle
CAR-T-2-M323-4G	Anti-NY-ESO-1 scFv h(CD4-FcεRIγ) CART, pCDCAR1
TCR-L155	Human anti-NY-ESO-1 T cell receptor (TCRCD8-NY#12), pCDTCR1
VP-TCR-C066	Lenti-NY-ESO-1 T cell receptor (TCRCD4-NY#10) Viral Particle
CAR-T-2-M323-8Z	Anti-NY-ESO-1 scFv h(CD8-CD3ζ) CART, pCDCAR1

Carcinoma Kits for CARs/TCRs Development

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pCDCAR1 NY-ESO-1 h(BBζ), T(CAR-T-2-M323-BZ)

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