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C9orf72

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The protein encoded by this gene plays an important role in the regulation of endosomal trafficking, and has been shown to interact with Rab proteins that are involved in autophagy and endocytic transport. Expansion of a GGGGCC repeat from 2-22 copies to 700-1600 copies in the intronic sequence between alternate 5' exons in transcripts from this gene is associated with 9p-linked ALS (amyotrophic lateral sclerosis) and FTD (frontotemporal dementia). The protein may be involved in regulating the maturation of phagosomes to lysosomes (By similarity). Regulates actin dynamics in motor neurons by inhibiting the GTP-binding activity of ARF6, leading to ARF6 inactivation.
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CAT Product Name Target Species Antibody Clone Antibody Host Receptor Construction Vector Type Targeting Cell Type CAR Vector Type Inquiry & Datasheet
CAR-CN086 Anti-C9orf72 (XHM79) h(CD28-CD3ζ) CAR, pCDCAR1 Human XHM79 Human scFv-CD28-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-CN187 Anti-C9orf72 (XHM79) h(41BB-CD3ζ) CAR, pCDCAR1 Human XHM79 Human scFv-41BB-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
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