CE7 is a L1CAM specific monoclonal antibody, it binds to an epitope on the L1 adhesion molecule with high affinity. L1 is an immunoglobulin superfamily high-molecular-mass glycoprotein of approximately 200kDa that mediates homophilic cell-cell adhesion. CE7 appears to bind to a tumor-specific epitope on L1CAM based on aberrant splice variants expressed by tumor cells. Subsequent work discovered that L1CAM is expressed in many human cancers and is often associated with bad prognosis.
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