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Fibroblast activation protein (FAP)

Fibroblast activation protein alpha (FAP) also called FAPA is a melanoma membrane-bound gelatinase, which encoded by the FAP gene in human. This protein a homodimeric integral membrane gelatinase belonging to the serine protease family. FAP is selectively expressed in reactive stromal fibroblasts of epithelial cancers, granulation tissue of healing wounds and malignant cells of bone and soft tissue sarcomas. Therefore, this protein is associated with epithelial cancers, breast cancer, colorectal cancer, skin cancer, pancreatic carcinomas, hepatocellular carcinomas, ovarian carcinomas and gastrointestinal carcinomas.

Associated Disease
  • CAR Vector Products
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CAT Product Name Target SpeciesAntibody CloneAntibody HostReceptor ConstructionVector TypeTargeting Cell Type Inquiry & Datasheet
CAR-LC223 Anti-FAP (73.3) h(CD28-CD3ζ) CAR, pCDCAR1 Mouse 73.3 Mouse scFv-CD28-CD3ζ Retroviral T cell   Add to Cart   Datasheet
CAR-LC224 Anti-FAP (73.3) h(41BB-CD3ζ) CAR, pCDCAR1 Mouse 73.3 Mouse scFv-41BB-CD3ζ Retroviral T cell   Add to Cart   Datasheet
CAR-MZ182 Anti-FAP (mAb 73.3) h(CD28-CD3ζ) CAR, pCDCAR1 Human mAb 73.3 Mouse scFv-CD28-CD3ζ Retroviral T cell   Add to Cart   Datasheet
CAR-MZ141 Anti-FAP (MO36) h(CD28-CD3ζ) CAR, pCDCAR1 Human, Mouse MO36 Mouse scFv-CD28-CD3ζ Retroviral T cell   Add to Cart   Datasheet
CAR-MZ142 Anti-FAP (MO36) h(41BB-CD3ζ) CAR, pCDCAR1 Human, Mouse MO36 Mouse scFv-41BB-CD3ζ Retroviral T cell   Add to Cart   Datasheet
CAR-MZ143 Anti-FAP (MO36) h(CD28-41BB-CD3ζ) CAR, pCDCAR1 Human, Mouse MO36 Mouse scFv-CD28-41BB-CD3ζ Retroviral T cell   Add to Cart   Datasheet

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