Fibroblast activation protein alpha (FAP) also called FAPA is a melanoma membrane-bound gelatinase, which encoded by the FAP gene in human. This protein a homodimeric integral membrane gelatinase belonging to the serine protease family. FAP is selectively expressed in reactive stromal fibroblasts of epithelial cancers, granulation tissue of healing wounds and malignant cells of bone and soft tissue sarcomas. Therefore, this protein is associated with epithelial cancers, breast cancer, colorectal cancer, skin cancer, pancreatic carcinomas, hepatocellular carcinomas, ovarian carcinomas and gastrointestinal carcinomas.
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