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FIP1L1

All products and services are For Research Use Only and CANNOT be used in the treatment or diagnosis of disease.

This gene encodes a subunit of the CPSF (cleavage and polyadenylation specificity factor) complex that polyadenylates the 3' end of mRNA precursors. This gene, the homolog of yeast Fip1 (factor interacting with PAP), binds to U-rich sequences of pre-mRNA and stimulates poly(A) polymerase activity. Its N-terminus contains a PAP-binding site and its C-terminus an RNA-binding domain. An interstitial chromosomal deletion on 4q12 creates an in-frame fusion of human genes FIP1L1 and PDGFRA (platelet-derived growth factor receptor, alpha). The FIP1L1-PDGFRA fusion gene encodes a constitutively activated tyrosine kinase that joins the first 233 amino acids of FIP1L1 to the last 523 amino acids of PDGFRA. This gene fusion and chromosomal deletion is the cause of some forms of idiopathic hypereosinophilic syndrome (HES). This syndrome, recently reclassified as chronic eosinophilic leukemia (CEL), is responsive to treatment with tyrosine kinase inhibitors. Alternative splicing results in multiple transcript variants encoding distinct isoforms.
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CAT Product Name Target Species Antibody Clone Antibody Host Receptor Construction Vector Type Targeting Cell Type CAR Vector Type Inquiry & Datasheet
CAR-CQ0984 Anti-FIP1L1 (CBXF-0684) h(41BB-CD3ζ) CAR, pCDCAR1 Human CBXF-0684 Mouse scFv-41BB-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-CQ0985 Anti-FIP1L1 (CBXF-3033) h(41BB-CD3ζ) CAR, pCDCAR1 Human CBXF-3033 Mouse scFv-41BB-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-CQ4408 Anti-FIP1L1 (CBXF-0684) h(CD28-CD3ζ) CAR, pCDCAR1 Human CBXF-0684 Mouse scFv-CD28-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-CQ4409 Anti-FIP1L1 (CBXF-3033) h(CD28-CD3ζ) CAR, pCDCAR1 Human CBXF-3033 Mouse scFv-CD28-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-WFY0731 Anti-FIP1L1 (CBFYH-0199) h(41BB-CD3ζ) CAR, pCDCAR1 Human CBFYH-0199 Mouse scFv-41BB-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-WFY3984 Anti-FIP1L1 (CBFYH-0199) h(CD28-CD3ζ) CAR, pCDCAR1 Human CBFYH-0199 Mouse scFv-CD28-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
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