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GRN

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Granulins are a family of secreted, glycosylated peptides that are cleaved from a single precursor protein with 7.5 repeats of a highly conserved 12-cysteine granulin/epithelin motif. The 88 kDa precursor protein, progranulin, is also called proepithelin and PC cell-derived growth factor. Cleavage of the signal peptide produces mature granulin which can be further cleaved into a variety of active, 6 kDa peptides. These smaller cleavage products are named granulin A, granulin B, granulin C, etc. Epithelins 1 and 2 are synonymous with granulins A and B, respectively. Both the peptides and intact granulin protein regulate cell growth. However, different members of the granulin protein family may act as inhibitors, stimulators, or have dual actions on cell growth. Granulin family members are important in normal development, wound healing, and tumorigenesis.
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CAT Product Name Target Species Antibody Clone Antibody Host Receptor Construction Vector Type Targeting Cell Type CAR Vector Type Inquiry & Datasheet
CAR-WFY0878 Anti-GRN (CBFYH-0497) h(41BB-CD3ζ) CAR, pCDCAR1 Human CBFYH-0497 Mouse scFv-41BB-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-WFY0879 Anti-GRN (CBFYH-0498) h(41BB-CD3ζ) CAR, pCDCAR1 Human CBFYH-0498 Mouse scFv-41BB-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-WFY0880 Anti-GRN (CBFYH-0499) h(41BB-CD3ζ) CAR, pCDCAR1 Human CBFYH-0499 Rabbit scFv-41BB-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-WFY4131 Anti-GRN (CBFYH-0497) h(CD28-CD3ζ) CAR, pCDCAR1 Human CBFYH-0497 Mouse scFv-CD28-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-WFY4132 Anti-GRN (CBFYH-0498) h(CD28-CD3ζ) CAR, pCDCAR1 Human CBFYH-0498 Mouse scFv-CD28-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-WFY4133 Anti-GRN (CBFYH-0499) h(CD28-CD3ζ) CAR, pCDCAR1 Human CBFYH-0499 Rabbit scFv-CD28-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
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