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KLHL25

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Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for translational homeostasis. The BCR(KLHL25) ubiquitin ligase complex acts by mediating ubiquitination of hypophosphorylated EIF4EBP1 (4E-BP1): ubiquitination and subsequent degradation of hypophosphorylated EIF4EBP1 (4E-BP1) probably serves as a homeostatic mechanism to maintain translation and prevent eIF4E inhibition when eIF4E levels are low. The BCR(KLHL25) complex does not target EIF4EBP1 (4E-BP1) when it is hyperphosphorylated or associated with eIF4E.
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CAT Product Name Target Species Antibody Clone Antibody Host Receptor Construction Vector Type Targeting Cell Type CAR Vector Type Inquiry & Datasheet
CAR-LY844 Anti-KLHL25 (13B459) h(41BB-CD3ζ) CAR, pCDCAR1 Human 13B459 Mouse scFv-41BB-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-LY845 Anti-KLHL25 (1B7) h(41BB-CD3ζ) CAR, pCDCAR1 Human 1B7 Mouse scFv-41BB-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-LY846 Anti-KLHL25 (1E9) h(41BB-CD3ζ) CAR, pCDCAR1 Human 1E9 Mouse scFv-41BB-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-LY2484 Anti-KLHL25(13B459) h(CD28-CD3ζ) CAR, pCDCAR1 Human 13B459 Mouse scFv-CD28-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-LY2485 Anti-KLHL25(1B7) h(CD28-CD3ζ) CAR, pCDCAR1 Human 1B7 Mouse scFv-CD28-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-LY2486 Anti-KLHL25(1E9) h(CD28-CD3ζ) CAR, pCDCAR1 Human 1E9 Mouse scFv-CD28-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
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