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LDLRAP1

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LDLRAP1 is a cytosolic protein which contains a phosphotyrosine binding (PTD) domain. The PTD domain has been found to interact with the cytoplasmic tail of the LDL receptor. Mutations in this gene lead to LDL receptor malfunction and cause the disorder autosomal recessive hypercholesterolaemia. Diseases associated with LDLRAP1 include Hypercholesterolemia, Autosomal Recessive and Homozygous Familial Hypercholesterolemia. Among its related pathways are Lipoprotein metabolism and Metabolism. Gene Ontology (GO) annotations related to this gene include phosphatidylinositol-4,5-bisphosphate binding and amyloid-beta binding. An important paralog of this gene is NUMBL.Adapter protein (clathrin-associated sorting protein (CLASP)) required for efficient endocytosis of the LDL receptor (LDLR) in polarized cells such as hepatocytes and lymphocytes, but not in non-polarized cells (fibroblasts). May be required for LDL binding and internalization but not for receptor clustering in coated pits. May facilitate the endocytocis of LDLR and LDLR-LDL complexes from coated pits by stabilizing the interaction between the receptor and the structural components of the pits. May also be involved in the internalization of other LDLR family members. Binds to phosphoinositides, which regulate clathrin bud assembly at the cell surface. Required for trafficking of LRP2 to the endocytic recycling compartment which is necessary for LRP2 proteolysis, releasing a tail fragment which translocates to the nucleus and mediates transcriptional repression (By similarity).
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CAT Product Name Target Species Antibody Clone Antibody Host Receptor Construction Vector Type Targeting Cell Type CAR Vector Type Inquiry & Datasheet
CAR-YJ059 Anti-LDLRAP1 (1F3) h(41BB-CD3ζ) CAR, pCDCAR1 Human 1F3 Mouse scFv-41BB-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-YJ060 Anti-LDLRAP1 (2B2) h(41BB-CD3ζ) CAR, pCDCAR1 Human 2B2 Mouse scFv-41BB-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-YJ061 Anti-LDLRAP1 (3H10) h(41BB-CD3ζ) CAR, pCDCAR1 Human 3H10 Mouse scFv-41BB-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-YJ062 Anti-LDLRAP1 (4B10) h(41BB-CD3ζ) CAR, pCDCAR1 Human 4B10 Mouse scFv-41BB-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-YJ063 Anti-LDLRAP1 (4G4-D5) h(41BB-CD3ζ) CAR, pCDCAR1 Human 4G4-D5 Mouse scFv-41BB-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-YJ064 Anti-LDLRAP1 (4G5) h(41BB-CD3ζ) CAR, pCDCAR1 Human 4G5 Mouse scFv-41BB-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-YJ065 Anti-LDLRAP1 (5A12) h(41BB-CD3ζ) CAR, pCDCAR1 Human 5A12 Mouse scFv-41BB-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-YJ066 Anti-LDLRAP1 (7 E11) h(41BB-CD3ζ) CAR, pCDCAR1 Human 7 E11 Mouse scFv-41BB-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-YJ067 Anti-LDLRAP1 (7H10) h(41BB-CD3ζ) CAR, pCDCAR1 Human 7H10 Mouse scFv-41BB-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-YJ559 Anti-LDLRAP1 (1F3) h(CD28-CD3ζ) CAR, pCDCAR1 Human 1F3 Mouse scFv-CD28-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-YJ560 Anti-LDLRAP1 (2B2) h(CD28-CD3ζ) CAR, pCDCAR1 Human 2B2 Mouse scFv-CD28-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-YJ561 Anti-LDLRAP1 (3H10) h(CD28-CD3ζ) CAR, pCDCAR1 Human 3H10 Mouse scFv-CD28-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-YJ562 Anti-LDLRAP1 (4B10) h(CD28-CD3ζ) CAR, pCDCAR1 Human 4B10 Mouse scFv-CD28-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-YJ563 Anti-LDLRAP1 (4G4-D5) h(CD28-CD3ζ) CAR, pCDCAR1 Human 4G4-D5 Mouse scFv-CD28-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-YJ564 Anti-LDLRAP1 (4G5) h(CD28-CD3ζ) CAR, pCDCAR1 Human 4G5 Mouse scFv-CD28-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-YJ565 Anti-LDLRAP1 (5A12) h(CD28-CD3ζ) CAR, pCDCAR1 Human 5A12 Mouse scFv-CD28-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-YJ566 Anti-LDLRAP1 (7 E11) h(CD28-CD3ζ) CAR, pCDCAR1 Human 7 E11 Mouse scFv-CD28-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-YJ567 Anti-LDLRAP1 (7H10) h(CD28-CD3ζ) CAR, pCDCAR1 Human 7H10 Mouse scFv-CD28-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
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