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NUDT16L1

All products and services are For Research Use Only and CANNOT be used in the treatment or diagnosis of disease.

Key regulator of TP53BP1 required to stabilize TP53BP1 and regulate its recruitment to chromatin (PubMed:28241136). In absence of DNA damage, interacts with the tandem Tudor-like domain of TP53BP1, masking the region that binds histone H4 dimethylated at Lys-20 (H4K20me2), thereby preventing TP53BP1 recruitment to chromatin and maintaining TP53BP1 localization to the nucleus (PubMed:28241136). Following DNA damage, ATM-induced phosphorylation of TP53BP1 and subsequent recruitment of RIF1 leads to dissociate NUDT16L1/TIRR from TP53BP1, unmasking the tandem Tudor-like domain and allowing recruitment of TP53BP1 to DNA double strand breaks (DSBs) (PubMed:28241136). Binds U8 snoRNA (PubMed:18820299).
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CAT Product Name Target Species Antibody Clone Antibody Host Receptor Construction Vector Type Targeting Cell Type CAR Vector Type Inquiry & Datasheet
CAR-CQ1637 Anti-NUDT16L1 (CBXS-1644) h(41BB-CD3ζ) CAR, pCDCAR1 Mouse, Rat, Human CBXS-1644 Rabbit scFv-41BB-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-CQ5061 Anti-NUDT16L1 (CBXS-1644) h(CD28-CD3ζ) CAR, pCDCAR1 Mouse, Rat, Human CBXS-1644 Rabbit scFv-CD28-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-0320ZP1581 Anti-NUDT16L1 (DS2515AB) h(CD28-CD3ζ) CAR, pCDCAR1 Human DS2515AB Rabbit scFv-CD28-CD3ζ Lentiviral vector T Cell   Add to Cart   Datasheet
CAR-0320ZP1582 Anti-NUDT16L1 (DS2515AB) h(4-1BB-CD3ζ) CAR, pCDCAR1 Human DS2515AB Rabbit scFv-4-1BB-CD3ζ Lentiviral vector T Cell   Add to Cart   Datasheet
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