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This gene encodes the coiled-coil containing protein optineurin. Optineurin may play a role in normal-tension glaucoma and adult-onset primary open angle glaucoma. Optineurin interacts with adenovirus E3-14.7K protein and may utilize tumor necrosis factor-alpha or Fas-ligand pathways to mediate apoptosis, inflammation or vasoconstriction. Optineurin may also function in cellular morphogenesis and membrane trafficking, vesicle trafficking, and transcription activation through its interactions with the RAB8, huntingtin, and transcription factor IIIA proteins. Alternative splicing results in multiple transcript variants encoding the same protein.
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CAT Product Name Target Species Antibody Clone Antibody Host Receptor Construction Vector Type Targeting Cell Type CAR Vector Type Inquiry & Datasheet
CAR-CQ1675 Anti-OPTN (CBXO-0412) h(41BB-CD3ζ) CAR, pCDCAR1 Human CBXO-0412 Mouse scFv-41BB-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-CQ1676 Anti-OPTN (CBXO-0069) h(41BB-CD3ζ) CAR, pCDCAR1 Human CBXO-0069 Mouse scFv-41BB-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-CQ1677 Anti-OPTN (CBXO-0178) h(41BB-CD3ζ) CAR, pCDCAR1 Human CBXO-0178 Mouse scFv-41BB-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-CQ5099 Anti-OPTN (CBXO-0412) h(CD28-CD3ζ) CAR, pCDCAR1 Human CBXO-0412 Mouse scFv-CD28-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-CQ5100 Anti-OPTN (CBXO-0069) h(CD28-CD3ζ) CAR, pCDCAR1 Human CBXO-0069 Mouse scFv-CD28-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-CQ5101 Anti-OPTN (CBXO-0178) h(CD28-CD3ζ) CAR, pCDCAR1 Human CBXO-0178 Mouse scFv-CD28-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
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