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PTEN

All products and services are For Research Use Only and CANNOT be used in the treatment or diagnosis of disease.

This gene was identified as a tumor suppressor that is mutated in a large number of cancers at high frequency. The protein encoded by this gene is a phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase. It contains a tensin like domain as well as a catalytic domain similar to that of the dual specificity protein tyrosine phosphatases. Unlike most of the protein tyrosine phosphatases, this protein preferentially dephosphorylates phosphoinositide substrates. PTEN is a multi-functional tumor suppressor that is very commonly lost in human cancer. Observed in prostate cancer, glioblastoma, endometrial, lung and breast cancer to varying degrees. Up to 70% of prostate cancer patients have been observed to have loss of expression of the gene. It is a part of the PI3K/AKT/mTOR pathway and mTOR inhibitors have been relatively ineffective in treating patients with PTEN loss. New appoaches using microRNAs are currently being investigated.
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CAT Product Name Target Species Antibody Clone Antibody Host Receptor Construction Vector Type Targeting Cell Type CAR Vector Type Inquiry & Datasheet
CAR-CQ1786 Anti-PTEN (10BA32) h(41BB-CD3ζ) CAR, pCDCAR1 Human 10BA32 Mouse scFv-41BB-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-CQ1787 Anti-PTEN (10BA34) h(41BB-CD3ζ) CAR, pCDCAR1 Human 10BA34 Mouse scFv-41BB-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-CQ5210 Anti-PTEN (10BA32) h(CD28-CD3ζ) CAR, pCDCAR1 Human 10BA32 Mouse scFv-CD28-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-CQ5211 Anti-PTEN (10BA34) h(CD28-CD3ζ) CAR, pCDCAR1 Human 10BA34 Mouse scFv-CD28-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
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