TAF1

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Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is the basal transcription factor TFIID, which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes the largest subunit of TFIID. This subunit binds to core promoter sequences encompassing the transcription start site. It also binds to activators and other transcriptional regulators, and these interactions affect the rate of transcription initiation. This subunit contains two independent protein kinase domains at the N- and C-terminals, but also possesses acetyltransferase activity and can act as a ubiquitin-activating/conjugating enzyme. Mutations in this gene result in Dystonia 3, torsion, X-linked, a dystonia-parkinsonism disorder. Alternative splicing of this gene results in multiple transcript variants. This gene is part of a complex transcription unit (TAF1/DYT3), wherein some transcript variants share exons with TAF1 as well as additional downstream DYT3 exons. [provided by RefSeq, Oct 2013]

CAR Vector Products
DMAb

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CAT	Product Name	Target Species	Antibody Clone	Antibody Host	Receptor Construction	Vector Type	Targeting Cell Type	CAR Vector Type	Inquiry & Datasheet
CAR-LY951	Anti-TAF1 (CBLY1-036) h(41BB-CD3ζ) CAR, pCDCAR1	Mouse, Rat, Human	CBLY1-036	Rabbit	scFv-41BB-CD3ζ	Lentiviral vector	T cell		Add to Cart Datasheet
CAR-LY952	Anti-TAF1 (0.T.145) h(41BB-CD3ζ) CAR, pCDCAR1	Mouse, Rat, Human	0.T.145	Mouse	scFv-41BB-CD3ζ	Lentiviral vector	T cell		Add to Cart Datasheet
CAR-LY2591	Anti-TAF1(CBLY1-036) h(CD28-CD3ζ) CAR, pCDCAR1	Mouse, Rat, Human	CBLY1-036	Rabbit	scFv-CD28-CD3ζ	Lentiviral vector	T cell		Add to Cart Datasheet
CAR-LY2592	Anti-TAF1(0.T.145) h(CD28-CD3ζ) CAR, pCDCAR1	Mouse, Rat, Human	0.T.145	Mouse	scFv-CD28-CD3ζ	Lentiviral vector	T cell		Add to Cart Datasheet
CAR-YJ200	Anti-TAF1 (1E11) h(41BB-CD3ζ) CAR, pCDCAR1	Human	1E11	Mouse	scFv-41BB-CD3ζ	Lentiviral vector	T cell		Add to Cart Datasheet
CAR-YJ700	Anti-TAF1 (1E11) h(CD28-CD3ζ) CAR, pCDCAR1	Human	1E11	Mouse	scFv-CD28-CD3ζ	Lentiviral vector	T cell		Add to Cart Datasheet

CAT	Product Name	Target Species	DMAb Clone	DMAb Host	DMAb Isotype	DMAb Cross Reactivity	Vector Name	Inquiry & Datasheet
DMAb-0200-YJ	Anti-TAF1 DNA-encoded mAb (DMAb), pVAX1	Human	1E11	Mouse	IgG1, κ	Human	pVAX1	Add to Cart Datasheet

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TAF1

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DMAb