Creative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsWith over a decade of experience in phage display technology, Creative Biolabs can provide a series of antibody or peptide libraries that are available for licensing or direct screening. These ready-to-use libraries are invaluable resources for isolating target-specific binders for various research, diagnostic or therapeutic applications. Highlights
Creative Biolabs has established a broad range of platforms for developing novel antibodies or equivalents. These cutting-edge technologies enable our scientists to meet your demands from different aspects and tailor the most appropriate solution that contributes to the success of your projects.
HighlightsWith deep understanding in antibody-related realms and extensive project experience, Creative Biolabs offers a variety of references to help you learn more about our capacities and achievements, including infographic, flyer, case study, peer-reviewed publications, and all kinds of knowledge that can assist your projects. You are also welcome to contact us directly for more specific solutions.
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HighlightsThe cation channels of sperm, also referred to as CatSper or Catsper channels, are ion channels that are correlated with two-pore channels and distantly correlated with TRP channels. It is known that ion channels can modulate the membrane potential and intracellular ionic concentration and thus play a pivotal role in many cellular processes. Several ion channels have been identified in germ cells, involving sperm, highlighting their significance in male fertility and reproduction. The presence of the sperm-associated cation channel (CatSper) gene family and other channel family members suggest an indispensable role for ion channels in sperm physiology and in fertility potential. Ion channels are the key players in very important processes such as capacitation and acrosome reaction. And CatSper family members are proposed to participate in acrosome reactions, thereby making them the most important for sperm fertility.
Here shows part of cation channel sperm-associated proteins in humans as bellows, including cation channel sperm-associated protein 1-4 (CATSPER1-4), cation channel sperm-associated protein subunit beta (CATSPERB), etc. CATSPER1-4, the four members of this family constitute voltage-gated Ca2+ channels that may be specific to sperm. When sperms encounter the more alkaline circumstance of the female reproductive tract, CatSper channels become activated by the altered ion concentration. Furthermore, these channels are required for proper fertilization.
| Human Cation Channel Sperm-associated Protein Family Members | ||||
| CATSPER1 | CATSPER2 | CATSPER3 | CATSPER4 | CATSPERB |
| CATSPERD | CATSPERE | CATSPERG | CATSPERZ | |
Aided by advanced Magic™ membrane protein production platform, Creative Biolabs is a pleasure to offer the preparation of these protein targets in required formats by various strategies, such as detergent micelles, proteoliposomes, nanodiscs, lipoparticles, polymers, stable cell line.
Meanwhile, our Magic™ membrane protein antibody discovery platform helps to discover antibodies against these targets, even fully humanized antibodies, using numerous approaches including hybridoma technology, phage display technology, and so on. We also present DNA immunization service for anti-membrane protein antibody development. Please feel free to contact us for more information.
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