Creative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs has established a broad range of platforms for developing novel antibodies or equivalents. These cutting-edge technologies enable our scientists to meet your demands from different aspects and tailor the most appropriate solution that contributes to the success of your projects.
HighlightsWith deep understanding in antibody-related realms and extensive project experience, Creative Biolabs offers a variety of references to help you learn more about our capacities and achievements, including infographic, flyer, case study, peer-reviewed publications, and all kinds of knowledge that can assist your projects. You are also welcome to contact us directly for more specific solutions.
HighlightsGet a real taste of Creative Biolabs, one of the most professional custom service providers in the world. We are committed to providing highly customized comprehensive solutions with the best quality to advance your projects.
Highlights| Protein Name | C-C chemokine receptor type 1 |
| Gene Name | CCR1 |
| Uniprot | P32246 (Human); P51675 (Mouse) |
| Synonym | CKR1; CD191; CKR-1; HM145; CMKBR1; MIP1aR; SCYAR1; C-C CKR-1; CC-CKR-1; CCR-1; LD78 receptor; MIP-1alpha-R; RANTES receptor; RANTES-R |
| Background | CCR-1 is a receptor for C-C type chemokine, which is encoded by CCR1 gene. Mapping to human chromosome 3p, the gene encoding C-C Motif Chemokine Receptor 1 (CCR1) occupies a characterized genomic locus noted for clustering several related chemokine receptor genes, namely CCR2, CCRL2, CCR3, CCR5, and CCXCR1. The CCR1 protein itself represents a landmark discovery, being the inaugural human CC chemokine receptor identified through cDNA cloning strategies. As a member of the beta chemokine receptor family, its primary structure predicts a canonical seven-transmembrane helical topology, aligning it with the G protein-coupled receptor (GPCR) superfamily. Investigations reveal predominant CCR1 expression across distinct leukocyte populations, critically including T cells, dendritic cells, monocytes, and neutrophils. |
Creative Biolabs offers comprehensive range of membrane protein products empowers your unique research needs.
| CAT# | Product Name | Expression System | Protein Length | Solubilizing Agents |
| S01YF-1023-KX400 | NativeExtract™ Human CCR1 Membrane Protein (Full length, Super Nanodisc) | HEK293 cells | Full length | Native Nanodisc |
| MPVLP-005 | MemDX™ Recombinant Human CCR1 Membrane Protein in Virus-Like Particles (MP-VLPs) | HEK293 cells | Full length | VLPs |
| MP1329J | MemDX™ Membrane Protein Human CCR1 (C-C motif chemokine receptor 1) for Antibody Discovery | E.colicell-free | Full length | Detergent |
| S01YF-0423-KX526 | MemDX™ Membrane Protein Human CCR1 (1-34aa) Expressed in HEK293, C-Human Fc tag | HEK293 cells | Partial | N/A |
| Please for more products or customization | ||||
J**n: MemDX™ Membrane Protein Human CCR1 (C-C motif chemokine receptor 1) for Antibody Discovery
Recombinant Human C-C Motif Chemokine Receptor 1 (CCR1) protein was procured from Creative Biolabs for experimental use. Initial quality assessment confirmed a high degree of purity for the preparation, a critical parameter impacting downstream assay reliability and data accuracy. Comprehensive documentation accompanying the reagent provided detailed specifications and essential handling protocols. Logistical processes ensured timely delivery, and the packaging methodology employed successfully maintained protein integrity upon arrival.
17/ Aug/2023
L**y: The technical support team from Creative Biolabs was very helpful, providing us with valuable advice and troubleshooting tips when we encountered any issues. This level of support is essential for us to achieve successful research outcomes.
03/Feb/2024
With our innovative approaches and comprehensive services, Creative Biolabs is dedicated to advancing CCR1 gene therapy. We provide tailored solutions to meet your specific requirements. Please for more services.
Creative Biolabs offers viral vector-based delivery services. Within advanced gene therapy, viral vectors stand as pivotal modalities for nucleic acid transfer, exhibiting significant plasticity for tailored cellular targeting, notably towards cell populations expressing the C-C Motif Chemokine Receptor 1 (CCR1). The directed transduction mediated by these engineered vectors enables the stable incorporation of the therapeutic transgene into the host cell's genomic architecture, a fundamental requisite for the enduring and protracted synthesis of the intended protein.
Creative Biolabs offers non-viral vector-based delivery services. Emerging as compelling alternatives to viral methodologies in gene transfer are non-viral delivery systems, strategically engineered to address inherent safety deficits associated with viral platforms, principally attenuating host immune responses and the potential for insertional mutagenesis. Cationic liposomes provide a salient example within this domain; these meticulously designed lipid-based nanocarriers facilitate the enclosure of nucleic acid payloads and subsequent cellular entry, predominantly through mechanistic pathways involving membrane fusion events or endocytic internalization.
Creative Biolabs offers exosome-mediated delivery services. Harnessing the inherent intercellular communication machinery, engineered exosomes are increasingly recognized as advanced nanocarriers for the targeted conveyance of functional RNA or protein payloads with specificity towards CCR1-expressing cells. These biologically derived nanoscale vesicles facilitate direct cytosolic release of their cargo through membrane fusion at the target cell interface, a particularly efficacious mechanism for the intracellular delivery of molecules such as small interfering RNAs (siRNAs) intended to elicit post-transcriptional suppression of CCR1 expression.
Creative Biolabs offers comprehensive and innovative services to drive the development of CCR1 cell therapy. Our commitment to excellence ensures the highest quality and reliability. Please for more services.
Creative Biolabs offers targeting CCR1-expressing myeloid cells production services. The expression of C-C Motif Chemokine Receptor 1 (CCR1) is established as a defining immunophenotypic characteristic for a diverse spectrum of myeloid lineage cells. Substantiating this, robust preclinical in vivo evidence confirms that targeted antibody administration against CCR1 effectively diminishes the tissue residency of these CCR1-positive myeloid populations. This pharmacological observation logically suggests a therapeutic rationale wherein such interventions could potentially curtail the infiltration of pro-tumorigenic myeloid cells within the tumor microenvironment, consequently altering the local immunoregulatory landscape.
Creative Biolabs offers dual blockade strategies research services. Simultaneous pharmacological antagonism targeting both C-C Motif Chemokine Receptor 1 (CCR1) and C-X-C Motif Chemokine Receptor 2 (CXCR2) elicits potent anti-neoplastic activity, significantly impeding primary tumor expansion and metastatic progression in preclinical models simulating human colorectal carcinoma (CRC).
All listed services and products are For Research Use Only. Do Not use in any diagnostic or therapeutic applications.
