CCR-10 Membrane Protein Introduction

Introduction Related Products Customer Reviews Customized Production Drug Discovery

Introduction of CCR10

Protein Name	C-C chemokine receptor type 10
Gene Name	CCR10
Uniprot	P46092 (Human); Q9JL21 (Mouse)
Synonym	GPR2; C-C chemokine receptor type 10; C-C CKR-10; CC chemokine receptor 10; CC-CKR-10
Background	CCR-10, previously known as GPR2, is encoded by the CCR10 gene. It is commonly expressed on melanocytes, plasma cells and memory T-cells (CLA⁺ T lymphocytes), where it functions in T-cell homing to inflamed skin. CCR-10 has been identified as the specific receptor for chemokines SCYA27 (CCL27) and SCYA28 (CCL28), which are a set of small (approximately 8 to 14 kD), structurally related molecules, and modulate cell trafficking of various leukocytes by means of interactions with a subset of seven-transmembrane, G protein-coupled receptors.

CCR10 Related Products

Membrane Protein Products

Creative Biolabs offers comprehensive range of membrane protein products empowers your unique research needs.

CAT#	Product Name	Expression System	Protein Length	Solubilizing Agents
S01YF-1023-KX294	NativeExtract™ Human CCR10 Membrane Protein (Full length, Super Nanodisc)	HEK293 cells	Full length	Native Nanodisc
MPVLP-011	MemDX™ Recombinant Human CCR10 Membrane Protein in Virus-Like Particles (MP-VLPs)	HEK293 cells	Full length	VLPs
MP1330J	MemDX™ Membrane Protein Human CCR10 (C-C motif chemokine receptor 10) for Antibody Discovery	E.colicell-free	Full length	Detergent
MP0168X	MemDX™ Membrane Protein Human CCR10 (C-C motif chemokine receptor 10) with GST-tag for Antibody Discovery	Wheat germ cell-free	Full length	N/A
MP0167X	MemDX™ Membrane Protein Human CCR10 (C-C motif chemokine receptor 10) without tag for Antibody Discovery	Wheat germ cell-free	Full length	Liposome
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Customer Reviews

D***ta: Creative Biolabs has truly delivered with their CCR10 protein. The product has shown excellent performance in my experiments, and the high quality is evident.

20/ Feb/2023

T***or: I had a great experience purchasing the CCR10 protein from Creative Biolabs. The protein arrived quickly and was in excellent condition. It has performed very well in my experiments, and the quality is top-notch. The customer service team was very helpful and provided valuable support.

12/ Feb /2024

Customized Membrane Protein Production

Different membrane protein formats (Creative Biolabs Original)

CCR10 Drug Discovery and Development

CCR10 Small Molecule Drug Development

Small molecule drug development services (Creative Biolabs Original)

Anti-CCR10 Antibody Discovery

Processes of antibody discovery (Creative Biolabs Original)

CCR10 Gene Therapy Development

We provide tailored solutions to meet your specific requirements. Please inquire us for more services.

Knockout and Knock-in Mouse Models

Creative Biolabs offers knockout and knock-in mouse models. Elucidating the diverse biological functions attributed to the chemokine receptor CCR10 often necessitates the implementation of sophisticated in vivo research paradigms. A principal and well-established methodology in this regard centers on the generation of genetically modified murine strains, specifically encompassing both knockout and knock-in variants. The development of these mouse models customarily relies upon the technique of targeted homologous recombination executed within embryonic stem cells. Such precisely engineered animal models furnish indispensable experimental platforms. Accordingly, they permit meticulous in vivo interrogation of CCR10's physiological activities, facilitating a detailed appraisal of its effects on complex cellular processes and, it may be speculated, its involvement in the initiation or progression of particular disease states.

Gene Expression Profiling and Pathway Analysis

Creative Biolabs offers gene expression profiling and pathway analysis services. Gene expression profiling can be used to identify downstream signaling pathways regulated by CCR10. For instance, studies have shown that CCR10 activation leads to the upregulation of the PI3K/Akt pathway, which is involved in cell proliferation and invasion. By analyzing gene expression data from high/low CCR10-expressing samples, researchers can identify potential therapeutic targets and signaling pathways that can be modulated to treat diseases associated with CCR10 overexpression.

CCR10 Cell Therapy Discovery

Creative Biolabs offers comprehensive and innovative services to drive the development of CCR10 cell therapy. Please inquire with us for more services.

Isolation and Characterization of CCR10-Expressing Cells

Creative Biolabs offers isolation and characterization of CCR10-expressing cells services. Conduct detailed phenotypic analysis of isolated CCR10-positive cells using flow cytometry and immunohistochemistry. This helps in understanding the cell type-specific roles of CCR10, such as in γδ T cells for skin-specific immune responses.

Genetic Modification of CCR10-Expressing Cells

Creative Biolabs offers genetic modification of CCR10-expressing cells services. Employ lentiviral or retroviral vectors to overexpress or knockdown CCR10 in target cells. This approach can be used to study the effects of altered CCR10 expression on cell behavior, such as in immune cell function and cancer cell biology.

With decades of experience and advanced technology, the membrane protein service team in Creative Biolabs offers the high-quality, reliable solutions to support our clients and will spare no effort to advance their research and programs of membrane protein preparation. Please feel free to contact us for more information.

All listed services and products are For Research Use Only. Do Not use in any diagnostic or therapeutic applications.

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